$B4AJ}Lt(B($B0lHLMQ0eLtIJ(B)
$B@=B$%a!<%+!

$B%D%`%i$N0lHLMQ4AJ}@=:^(B

$BBg;34AJ}Lt6I!!>&IJ(B
$B%D%`%i0lHLMQ4AJ}@=:^(B
$BA4IJL\(B


$B!!(B$B!!(B$B!!(B

$B!V<+A3$H7r9/$r2J3X$9$k!W(B
$B%D%`%i0lHLMQ4AJ}%(%-%9@=:^(B
$BA4IJL\(B


$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)





$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)


$B!JCm0U!KBg;34AJ}F2Lt6I$NDL>o2A3J$O!"%a!<%+!<4uK>>.Gd2A3J$G$9!#(B

$B!!(B$B!!(B$B!!(B

$B%D%`%i0lHLMQ4AJ}%(%-%9@=:^(B
$B$*$h$S%D%`%i0lHLMQ4AJ}Lt(B
$BA4IJL\$N2r@b(B
$B!J3t<02q$B!K(B

$B!!!!(B$B!!!!(B

$B-!4AJ}Lt$O!"$*5RMM$NBNI>u$rAm9gE*!&5R4QE*$K?GCG$7$F$+$i=hJ}$r7h$a$^$9!#(B
$BAG?MH=CG$G4AJ}Lt$rI~MQ$7B3$1$k$H!"8z2L$,8=$l$J$$$P$+$j$+!"(B
$B$+$($C$FBN$KJQD4$r$-$?$9$3$H$K$b$J$j$+$M$^$;$s!#4AJ}Lt$OI,$:Lt6I!&LtE9$G$4AjCL$N>e$*5a$a$/$@$5$$!#(B
$B-"D9$$Nr;K$HK-$+$J7P83$,$"$j$^$9(B
$B!V4AJ}!W$H$O!"Cf9q$+$iEAMh$7$F$-$?0e3X!&Lt3X$NAm>N$G$9!#(B
$B$=$NNr;K$OFs@iG/$H$b;0@iG/$H$b$$$o$l!"D9$$G/7n$r$+$1$FF@$?5.=E$J7P83$,4pHW$K$J$C$F$$$^$9!#(B
$B-#<+A3$r=E;k$7$^$9(B
$B86NA$OE7A3$NAp:,LZHi!#<#NE$N:]$b!"$=$N?M$,@8Mh;}$C$F$$$k<+A3<#L~NO$r=E;k$7!"(B
$B4AJ}$O$"$/$^$G!"BN$N2sI|$r%P%C%/%"%C%W$9$k$b$N$H$$$&8+J}$r$7$F$$$^$9!#(B
$B-$A4BN$ND4OB$r$O$+$j$^$9(B
$B<+A3<#L~NO$r9b$a$k$?$a!"6IItE*$J>I>u$K$H$i$o$l$:!"(B
$B%+%i%@A4BN$N%P%i%s%9$r@0$($k$3$H$r=E;k!#(B
$B?4?H$N$5$^$6$^$J$R$:$_$r@'@5$9$k$H$H$b$K!"B>$N>I>u$b4KOB$7$^$9!#(B
$B-%8D?M:9$rBg@Z$K$7$^$9(B
$BIBL>$@$1$GEjLt$d<#NE$r$9$k$3$H$J$/!"$=$N?M$NBNNO$dBN $B$=$N7k2L!"?tB?$/$N=hJ}$NCf$+$i$=$N?M$KE,9g$9$k=hJ}$,A*$P$l$^$9!#(B

$B$*Ld$$9g$o$;$O!"(B
$B4AJ}$r8=BeIB$K3h$+$9!*4AJ}@lLg!!Bg;34AJ}F2Lt6I(B
0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B
$B$^$G!"$*5$7Z$K$*Ld$$9g$o$;$/$@$5$$!#(B


$BBg;34AJ}F2Lt6I(B
$B4AJ}7r9/AjCL%3!<%J!<$X!"%/%j%C%/!*(B




$B:4LnLq=|$1Bg;UDL$j$N4AJ}@lLg!"Bg;34AJ}F2Lt6I!!(BWeb-Page $B$X!"#G#o!*!*!*(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B0eLtIJ$O;HMQ>e$NCm0U$r$*FI$_$$$?$@$-!"@5$7$/$*;H$$$/$@$5$$!#(B
$B$*Gc$$5a$a$N:]$K$O!"4AJ}$r8=BeIB$K3h$+$9(B $B4AJ}@lLg(B $BBg;34AJ}Lt6I$K!"$*5$7Z$K$4AjCL$/$@$5$$!#(B


$B!V%$%s%?!<%M%C%H$G8+$?!*!W(B
$B$H$*OC$/$@$5$$!#(B


$B!JCm0U!K(B
$B4AJ}@lLg!!Bg;34AJ}F2Lt6I$N!!87A*!"4AJ}Lt!"7r9/?)IJ$N$4CmJ8$O!"Bg;34AJ}Lt6I$K!"D>@\!"$*EEOC!"(BFAX$B!"(BE-mail $B$K$F$4MQL?$/$@$5$$!#(B

$B$*EEOC!'(B0283-22-1574$B!"(BFAX$B!'(B0283-22-1607$B!"(BE-mail:ohyama@poem.ocn.ne.jp
$B$*BT$ACW$7$F$*$j$^$9!#(B


$B!VBg;34AJ}F2(B $B4AJ}0e3X$H4AJ}7r9/AjCL!W(B

$B!!!!!!!!!!(B$B!!(B$BBg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B


" THE KAMPO " $B4AJ}(B
$B!!4AJ}Lt(B, How the Japanese Updated Traditional Herbal Medicine


$B!c4AJ}Lt$N$4I~MQ$r$*9M$($N3'MM$X$N$*4j$$!*!d(B

$B!v4AJ}Lt$N$4I~MQ$K4X$7$^$7$F$O!"(B
$B!V;HMQ>e$NCm0U!W$r$h$/FI$_!"!VMQK!!&MQNL!W$r$h$/
$B$^$?!":#2s!";O$a$F!"4AJ}Lt$N$4I~MQ$r4uK>$5$l$k$*5RMM$O!"(B
$B2<5-!"Ld?GI=$KI,MW;v9`$r5-F~$7$FAw?.$9$k$+!"(B

$B4AJ}AjCL$*?=$79~$_%U%)!<%`(B

$B$*EEOC$K$F!"D>@\!"Bg;34AJ}Lt6I$K!"$4AjCL$/$@$5$$!#(B
$B>I>u!&BN\$7$/$*;G$$$7$?>e$G!"E,@Z$J4AJ}Lt$r%"%I%P%$%9$5$;$FD:$-$^$9!#(B

$B!JBg;34AJ}Lt6I(B / $BL5NA4AJ}AjCLEEOC(B $B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4(B / $B#9!'#0#0!A#1#9!'#0#0!K(B

$B!cCm0U!d(B
$BBg;34AJ}Lt6I!"%G%8%?%kE9J^$G!"$*
$B0J>e!"$h$m$7$/$*4j$$CW$7$^$9!#(B

E-mail to Dr. Ohyama Kampo Pharmacy.


$B!!(B$B4AJ}$r8=BeIB$K3h$+$9!*!!4AJ}@lLg!!Bg;34AJ}Lt6I%G%8%?%kE9J^$X!*(B



$BBg;34AJ}F2Lt6I(B $B")(B327-0026$B!!FJLZ8):4Ln;T6b20CgD9D.#2#4#3#2(B
TEL$B!u(BFAX : 0283-22-1574$B!!(B E-mail : ohyama@poem.ocn.ne.jp

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B


$BFCJL3d0zM%BT2A3J!JA4IJ!"#28D$G#13d0z(B)


$BBNNO(B $B%D%`%i0lHLMQ4AJ}Lt(B
$BIB5$$H>I>u(B
$B%D%`%i0lHLMQ4AJ}Lt(B
$B;HMQL\I8!a>Z(B
$B%D%`%i0lHLMQ4AJ}Lt(B
$B>&IJL>!J=hJ}L>!K(B
$BJqAu7ABV!'HNGd2A3J!J@G9~!K(B
$B $B%+%<(B $B=i4|(B/$BH/G.!&4(5$!&F,DK$,$"$j!"(B
$B!!!!!!!!<+A3H/4@$9$k$3$H$,$J$/!"8*$,$3$k?M$K(B
$B%+%s%]%s%3!<%k(B
$B3k:,Er!J$+$C$3$s$H$&!K#S(B
$B#8Jq!J#4F|J,!K#1#2#0#01_(B
$B#1#6Jq!J#8F|J,!K#2#1#0#01_(B
$B $B%+%<(B $B=i4|(B/$BH/G.!&4(5$!&F,DK$,$7!"<+A3H/4@$9$k$3$H$,$J$/!"(B
$B!!!!!!!!BN$N$U$7$V$7$,DK$`?M$K(B
$B%+%s%]%s%3!<%k(B
$BKc2+Er!J$^$*$&$H$&!K#S(B
$B#8Jq!J#4F|J,!K#1#2#0#01_(B
$B5u!a $B%+%<(B $B=i4|(B/$B%+%<$N$R$-$O$8$a$G!"H/G.!&4(5$!&F,DK$,$9$k?M$K(B $B7K;^Er!J$1$$$7$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B%+%<(B $B8e4|(B/$BD90z$$$?%+%<$G!"HyG.!&4(5$$,$"$j!"?)M_$,L5$/(B
$B!!!!!!!!J"DK!&$O$-$1$J$I>C2=4o>I>u$rH<$&?M$K(B
$B $B!J$5$$$3$1$$$7$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$BCf!aCf(B $B%+%<(B $B8e4|(B/$B%+%<$N$"$H!"?)M_$,$J$/!"Hh$l$d$9$$?M$K(B $B>. $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$B5u!a $B%+%<(B $BJd:^(B/$B%+%<$N$"$H!"?)M_$,$J$/!"Hh$l$d$9$/!"(B
$B!!!!!!!!?j
$BJdCf1W5$Er(B
$B!J$[$A$e$&$($C$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$BCf!aCf(B $B$N$I!&$;$-(B $B$&$9$$%?%s$,B?NL$K=P$F!"%<%$%<%$$H$$$&$;$-$r$9$k?M$K(B $B>.@DN5Er!J$7$g$&$;$$$j$e$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $B$N$I!&$;$-(B $B%?%s$,$h$/@Z$l$:!"4i$,@V$/$J$k$[$I7c$7$$$;$-$r$9$k?M$K(B $BG~LgE_Er!J$P$/$b$s$I$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B$N$I!&$;$-(B $B$N$I!"?)F;It$K0[J*46$,$"$j!"$;$-$d(B
$B$7$o$,$l@<$N$9$k?M$K(B
$BH>2F8|KQEr(B
$B!J$O$s$2$3$&$\$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B$N$I!&$;$-(B $B$N$I$K0[J*46$,$"$j!"$;$-$r$9$k?M$K(B $B%+%s%]%"%:%^(B
$B#8Jq!J#4F|J,!K#1#2#0#01_(B
$B#1#6Jq!J#8F|J,!K#2#1#0#01_(B
$BCf!aCf(B $B$N$I!&$;$-(B $B$N$I$, $B%+%s%]%s%3!<%k(B
$B5K9 $B#8Jq!J#4F|J,!K#1#0#0#01_(B
$B $B$N$I!&$;$-(B $B$;$-$,7c$7$/!"?e$r0{$_$?$,$k?M$K(B $BKc0I4E@PEr!J$^$-$g$&$+$s$;$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $BI!?e!&I!$E$^$j(B $B$&$9$$?eMM$NI!?e$,B?$+$C$?$j!"%<%s%=%/$.$_$N?M$K(B $B>.@DN5Er!J$7$g$&$;$$$j$e$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $BI!?e!&I!$E$^$j(B $BC_G?>I!&K}@-I!1j$N?M$K(B $B7U3)O"fKEr!J$1$$$,$$$l$s$.$g$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B $BI!?e!&I!$E$^$j(B $BK}@-$NI!$E$^$j$dC_G?>I$N?M$K(B $B3k:,Er2C@n%-%e%&?I%$(B
$B!J$+$C$3$s$H$&$+$;$s$-$e$&$7$s$$!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$B5u!a $BF,DK(B $BNd$(>I$GIO7l$N798~$,$"$j!"(B
$BK}@-$NF,=E!&8*$3$j$,$"$k?M$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $BF,DK(B $BK}@-$KB3$/F,DK$GCfG/0J9_$N?M$K(B $BD`F#;6!J$A$g$&$H$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $BF,DK(B $B$N$I$,3i$$$F!"G"NL$,>/$J$/!"$O$-$1$rH<$&F,DK$K(B $B8^Nj;6NA!J$4$l$$$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $BF,DK(B $BHf3SE*BNNO$,$"$j!"IO7l$N798~$,$J$/!"B-$,Nd$(!"(B
$B$N$\$;$.$_$N?M$NF,DK$K(B
$B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $BF,DK(B $BG"NL8:>/!"B-Nd$(!"N)$A$/$i$_!"F0X)$J$I$rH<$&F,DK$K(B $BNj7K[24EEr!J$j$g$&$1$$$8$e$D$+$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $BF,DK(B $B9`GXIt$K$+$1$F6/$/6E$j!"F,DK$,$9$k?M$K(B $B3k:,Er!J$+$C$3$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B$$$i$$$i!&ITL2(B $BF0X)$,$"$j!JG"NL$,8:>/$7!K!"$a$^$$$d$U$i$D$-$,$"$k?M$K(B $BNj7K[24EEr!J$j$g$&$1$$$8$e$D$+$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B$$$i$$$i!&ITL2(B $B5$J,$,$U$5$$$G!"$N$I$K0[J*46$N$"$k?M$NIT0B?@7P>I$K(B $BH>2F8|KQEr!J$O$s$2$3$&$\$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B$$$i$$$i!&ITL2(B $B5u $B@:?@IT0B$J$I$N@:?@?@7P>I>u$K(B $B2CL#mvt#;6(B
$B!J$+$_$7$g$&$h$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $B$$$i$$$i!&ITL2(B $BHiIf$N?'$D$d$,0-$/!"$N$\$;$N$"$k?M$K(B $B29@60{!J$&$s$;$$$$$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B$$$i$$$i!&ITL2(B $B5u $B7K;^2CN59|24iZEr(B
$B!J$1$$$7$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $B$$$i$$$i!&ITL2(B $B@:?@IT0B!"F0X)!"ITL2$J$I$N@:?@?@7P>I>u$K(B $B $B!J$5$$$3$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $B$$$i$$$i!&ITL2(B $BHf3SE*BNNO$,$"$j!"$N$\$;$.$_$G!"(B
$B4i?'$,@V$/$$$i$$$i$9$k?M$NITL2!"?@7P>I$K(B
$B2+O"2rFGEr(B
$B!J$*$&$l$s$2$I$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B $B$$$i$$$i!&ITL2(B $BHf3SE*BNNO$,$"$j!"$N$\$;$FJXHk$N798~$G!"(B
$B7n7P;~$d;:8e$N@:?@IT0B$N?M$K(B
$BEm3K>55$Er(B
$B!J$H$&$+$/$8$g$&$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B5u!a $B8*$3$j(B $BNd$(>I$GIO7l$N798~$,$"$j!"7n7P0[>o!"(B
$B99G/4|>c32$rH<$&8*$3$j$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B8*$3$j(B $BHf3SE*BNNO$,$"$j!"IO7l$N798~$,$J$/!"B-$,Nd$(!"(B
$B$N$\$;$.$_$N?M$N8*$3$j$K(B
$B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$B $B8*$3$j(B $B $B3k:,Er!J$+$C$3$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$B $B8*$3$j(B $BBNNO$,$"$j!"JXHk$,$A$G!"8*$,$R$C$Q$i$l$k$h$&$K6E$k?M$K(B $BBg $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$BCf!aCf(B $B9b7l05$N>I>u(B $BCfG/0J9_$G9b7l05$N798~$K$"$k?M$NF,DK$K(B $BD`F#;6!J$A$g$&$H$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$B $B9b7l05$N>I>u(B $B$N$\$;!"4iLL9HD,!"ITL2!"5$J,$NIT0BDj$J$I$K(B $B2+O"2rFGEr!J$*$&$l$s$2$I$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B $B9b7l05$N>I>u(B $B7l05$,9b$/!"F0X)!"IT0B!"ITL2$rH<$&?M$K(B $B $B!J$5$$$3$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $B9b7l05$N>I>u(B $BHf3SE*BNNO$,$"$j!"$N$\$;$F!"JXHk$N798~$,$"$k?M$N(B
$B9b7l05$KH<$&F,DK!&$a$^$$!&8*$3$j$K(B
$BEm3K>55$Er(B
$B!J$H$&$+$/$8$g$&$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $B9b7l05$N>I>u(B $BJ"It$KHi2<;iKC$,B?$/!"JXHk$N798~$,$"$k?M$N(B
$B9b7l05$KH<$&F0X)!&8*$3$j!&$N$\$;$K(B
$BKIIwDL@;;6(B
$B!J$\$&$U$&$D$&$7$g$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$B $B9b7l05$N>I>u(B $B$,$C$7$j$H$7$?BN3J$GJXHk$N798~$N$"$k?M$N(B
$B9b7l05$KH<$&8*$3$j!"F,DK$K(B
$BBg $B!J$@$$$5$$$3$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$BCf!aCf(B $B$a$^$$(B $B$a$^$$!"$U$i$D$-$,$"$j!"(B
$B$^$?$OF0X)$,$"$jG"NL$,8:>/$9$k?M$K(B
$BNj7K[24EEr(B
$B!J$j$g$&$1$$$8$e$D$+$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $B$a$^$$(B $B$N$\$;5$L#$G!"ITL2!&%$%i%$%i$J$I(B
$B@:?@?@7P>I>u$rAJ$($k?M$N$a$^$$$K(B
$B2+O"2rFGEr(B
$B!J$*$&$l$s$2$I$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B5u!a $B0_D2$N%H%i%V%k(B $BHhO+46$,6/$/!"0_D2$N$O$?$i$-$,?j$($F$$$k?M$K(B $BJdCf1W5$Er!J$[$A$e$&$($C$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$B5u!a $B0_D2$N%H%i%V%k(B $B0_D2$, $B $BO;7/;REr(B
$B!J$j$C$/$s$7$H$&!K(B
$B#2#4Jq!J#1#2$K$A$V$s!K#4#0#0#01_(B
$B5u!a $B0_D2$N%H%i%V%k(B $B $B?M;2Er!J$K$s$8$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B5u!a $B0_D2$N%H%i%V%k(B $BAi$;7?$G!"J"It6ZFy$,CP4K$7$?$j$9$k798~$,$"$k?M$N(B
$B0_DK!&J"DK$K(B
$B0BCf;6NA(B
$B!J$"$s$A$e$&$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B5u!a $B0_D2$N%H%i%V%k(B $BBNNO$,5u $B7K;^2CgiLtBg2+Er(B
$B!J$1$$$7$+$7$c$/$d$/$@$$$*$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B0_D2$N%H%i%V%k(B $BHh$l$d$9$/!"0_ $B>. $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$BCf!aCf(B $B0_D2$N%H%i%V%k(B $B?@7P@-0_1j!"FpJX$^$?$O2 $BH>2F_C?4Er!J$O$s$2$7$c$7$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$BCf!aCf(B $B0_D2$N%H%i%V%k(B $B;~$KJ"DK$rH<$&0_D21j$K(B $B $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$BCf!aCf(B $B0_D2$N%H%i%V%k(B $B5$J,$,$U$5$.5$L#$G!"$H$-$KF0X)!&$a$^$$!"(B
$B$O$-$1$J$I$rH<$&?@7P@-0_1j$K(B
$BH>2F8|KQEr(B
$B!J$O$s$2$3$&$\$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B $B0_D2$N%H%i%V%k(B $BHf3SE*BNNO$,$"$j8*$,$3$j$d$9$/!"JXHk798~$N$"$k?M$K(B $BBg $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$BCf!aCf(B $B$O$-$1!&FsF|?l$$(B $B$N$I$,3i$-!"?e$r0{$`$HEG$-=P$7!"F,DK!"$O$-$1$rH<$&?M$K(B $B8^Nj;6NA!J$4$l$$$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B$O$-$1!&FsF|?l$$(B $B;~$KF0X)$rAJ$(!"$N$I$K0[J*46$,$"$j!"SR5$$N$"$k?M$K(B $BH>2F8|KQEr!J$O$s$2$3$&$\$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B$O$-$1!&FsF|?l$$(B $B$_$>$*$A$,$D$+$(!"$H$-$KSREG!"0-?4!"?)M_IT?6$rH<$&?M$K(B $BH>2F_C?4Er!J$O$s$2$7$c$7$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $B$O$-$1!&FsF|?l$$(B $BHf3SE*BNNO$,$"$j!"$N$\$;5$L#$G4i?'$,@V$/!"(B
$B$$$i$$$i$N$"$k?M$K(B
$B2+O"2rFGEr(B
$B!J$*$&$l$s$2$I$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B5u!a $B2C2=ITNI(B $BJ"ItKDK~$,$"$j!"2 $B2 $B7K;^2CgiLtBg2+Er(B
$B!J$1$$$7$+$7$c$/$d$/$@$$$*$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B5u!a $B2C2=ITNI(B $B0_D2$,5u $B?M;2Er!J$K$s$8$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B2C2=ITNI(B $B$N$I$,3i$-!"?e$r0{$`$H$9$0$KEG$/$h$&$J>l9g$K(B
$B5/$3$k2
$B8^Nj;6NA(B
$B!J$4$l$$$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B2C2=ITNI(B $B$_$>$*$A$,$D$+$($?$h$&$J46$8$,$7!"(B
$B$O$-$1$,$7$FJ"$,$J$C$?$j$9$k2
$BH>2F_C?4Er(B
$B!J$O$s$2$7$c$7$s$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $B$B<@45(B $BBgJX$,$+$?$/JXHk798~$N$"$k?M$G!"(B
$BFC$K%$%\<&$-$l<&$N?M$K(B
$B25;zEr(B
$B!J$*$D$8$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B5u!a $BJXHk(B $BJX$,=P$F$b$9$C$-$j$;$:!"J"ItKDK~$N?M$K(B $B7K;^2CgiLtBg2+Er(B
$B!J$1$$$7$+$7$c$/$d$/$@$$$*$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $BJXHk(B $B5u $B2CL#mvt#;6!J$+$_$7$g$&$h$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $BJXHk(B $B>o=,JXHk$K(B $BBg2+4EApEr!J$@$$$*$&$+$s$>$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $BJXHk(B $B$,$C$7$j$H$7$?BN3J$G!"8*$,$3$j$d$9$/!"(B
$BJX$,$+$?$/$F=P$J$$?M$K(B
$BBg $B!J$@$$$5$$$3$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $BJXHk(B $B<&$N798~$,$"$j!"JX$,$+$?$/$F=P$K$/$$?M$K(B $B25;zEr!J$*$D$8$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $BJXHk(B $BHf3SE*BNNO$,$"$j!"$N$\$;!"F,DK!"$a$^$$!"(B
$B8*$3$j$,$A$GJXHk$9$k?M$K(B
$BEm3K>55$Er(B
$B!J$H$&$+$/$8$g$&$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B $BJXHk(B $BJ"It$KHi2<;iKC$,B?$/!JB@8]J"!K!"JXHk$N798~$,$"$k?M$K(B $BKIIwDL@;;6!J$\$&$U$&$D$&$7$g$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$BCf!aCf(B $BHnK~(B $B?'Gr$GH/4@$7$d$9$/!"?e$V$H$j$N?M$K(B $BKIVa2+fMEr!J$\$&$$$*$&$.$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$B $BHnK~(B $B$,$C$7$j$H$7$?BN3J$G!"8*$3$j$,$"$j!"JXHk$N798~$K$"$k?M(B $BBg $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B $BHnK~(B $BJ"It$KHi2<;iKC$,B?$/!JB@8]J"!K!"JXHk$N798~$,$"$k?M$K(B $BKIIwDL@;;6!J$\$&$U$&$D$&$7$g$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$B5u!a $B$`$/$_(B $BNd$(>I$GIO7l$N798~$,$"$j!"$H$-$K7Z$$$a$^$$$d(B
$BF0X)$r<+3P$7!"7n7PIT=g$d7n7P;~$KBND4$K0[>o$,(B
$B$"$k?M$NA4?H$N$`$/$_$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B$`$/$_(B $B?e$V$H$j$G!"4@$r$+$-$d$9$/!"(B
$BHh$l$d$9$$?M$NA4?H$N$`$/$_$K(B
$BKIVa2+fMEr(B
$B!J$\$&$$$*$&$.$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$BCf!aCf(B $B$`$/$_(B $B$N$I$,3i$-!"G"NL$,>/$J$$?M$NA4?H$N$`$/$_$K(B $B8^Nj;6NA!J$4$l$$$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B $B$`$/$_(B $BJ"It$KHi2<;iKC$,B?$/!JB@8]J"!K!"JXHk$N798~$,$"$k?M$K(B $BKIIwDL@;;6!J$\$&$U$&$D$&$7$g$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$B5u!a $BIQG"!&GSG":$Fq(B $BHh$l$d$9$/!"8}3i$7!"Lk4VIQG"$"$k$$$OGSG":$Fq!"(B
$B$+$9$_L\$N?M$K(B
$BH,L#CO2+4]NA(B
$B!J$O$A$_$8$*$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#7#5#0#01_(B
$BCf!aCf(B $BIQG"!&GSG":$Fq(B $B$N$I$,3i$-!"G"NL$,>/$J$/!"$^$?A4?H$N$`$/$_$N$"$k?M$K(B $B8^Nj;6NA!J$4$l$$$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $BGSG"DK(B $BG"NL$,8:>/$7!"G"$,=P$K$/$/!"GSG"DK!";DG"46$N$"$k?M$K(B $BCvNjEr!J$A$g$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$B5u!a $BNd$(!&IO7l(B $BIO7l$N798~$,$"$j!"Hh$l$d$9$/!"F,=E46!"8*$3$j!"(B
$B$a$^$$$J$I$r$H$b$J$&Nd$(>I$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $BNd$(!&IO7l(B $B8*$,$3$j!"Hh$l$d$9$/!"$H$-$KJXHk798~$,$"$k?M$NNd$(>I!"99G/4|>c32$K(B $B2CL#mvt#;6(B
$B!J$+$_$7$g$&$h$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $BNd$(!&IO7l(B $BHf3SE*BNNO$,$"$j!"IO7l$N798~$,$J$/!"B-$,Nd$(!"(B
$B$N$\$;$.$_$N?M$K(B
$B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $BNd$(!&IO7l(B $BF0X)!&B)@Z$l$dN)$A$/$i$_$9$k?M$K(B $BNj7K[24EEr!J$j$g$&$1$$$8$e$D$+$s$H$&!K#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B5u!a $B99G/4|$N>I>u(B $BNd$(>I$GIO7l$N798~$,$"$j!"Hh$l$d$9$/!"F,=E46!"8*$3$j!"(B
$B$a$^$$$J$I$rH<$&99G/4|>c32!&7n7P:$Fq$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B99G/4|$N>I>u(B $B5u $B$H$-$KJXHk798~$,$"$k?M$K(B $B2CL#mvt#;6(B
$B!J$+$_$7$g$&$h$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#9#0#0#01_(B
$BCf!aCf(B $B99G/4|$N>I>u(B $BHf3SE*BNNO$,$"$j!"IO7l$N798~$,$J$/!"B-$,Nd$(!"(B
$B$N$\$;$.$_$N?M$N8*$3$j$K(B
$B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B99G/4|$N>I>u(B $BHiIf$N?'$D$d$,0-$/!"$N$\$;!"?@7P>I$N$"$k7n7PIT=g!"(B
$B7n7P:$Fq!"99G/4|>c32$K(B
$B29@60{(B
$B!J$&$s$;$$$$$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B99G/4|$N>I>u(B $B5$J,$,$U$5$$$G!"$N$I$K0[J*46$N$"$k?M$NIT0B?@7P>I$K(B $BH>2F8|KQEr!J$O$s$2$3$&$\$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B5u!a $B@8M}DK!&@8M}IT=g(B $BNd$(>I$GIO7l$N798~$,$"$j!"Hh$l$d$9$/!"F,=E46!"8*$3$j!"(B
$B$a$^$$$J$I$rH<$&?M$N7n7PDK!"7n7PIT=g$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B@8M}DK!&@8M}IT=g(B $BHf3SE*BNNO$,$"$j!"IO7l$N798~$,$J$/!"B-$,Nd$(!"(B
$B$N$\$;$.$_$N?M$K(B
$B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$B $B@8M}DK!&@8M}IT=g(B $BHf3SE*BNNO$,$"$j!"$N$\$;$FJXHk$,$A$N?M$K(B $BEm3K>55$Er!J$H$&$+$/$8$g$&$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B5u!a $B$K$-$S!&$7$C$7$s(B $BCfG/0J9_$N?M$G!"Lk4VIQG"$7!"(B
$BHiIf$,4%Ag$7$F$+$f$_$N$"$k>l9g$K(B
$BH,L#CO2+4]NA(B
$B!J$O$A$_$8$*$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#7#5#0#01_(B
$BCf!aCf(B $B$K$-$S!&$7$C$7$s(B $BI!"$7$C$7$s$d$8$s$^$7$s$K(B $B==L#GTFGEr!J$8$e$&$_$O$$$I$/$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$BCf!aCf(B $B$K$-$S!&$7$C$7$s(B $B$K$-$S$NItJ,$,@V$$?M$K(B $B@6>eKIIwEr!J$;$$$8$g$&$\$&$U$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B$K$-$S!&$7$C$7$s(B $BJ,HgJ*$,B?$/!"$+$f$_$N6/$$K}@-<>?>$K(B $B>CIw;6!J$7$g$&$U$&$5$s!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B$K$-$S!&$7$C$7$s(B $B45It$,2=G?$7$d$9$/!"(B
$B?>$K(B
$B7U3)O"fKEr(B
$B!J$1$$$,$$$l$s$.$g$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B$K$-$S!&$7$C$7$s(B $BHiIf$N?'$D$d$,0-$/!"$N$\$;$N$"$k?M$K(B $B29@60{!J$&$s$;$$$$$s!K(B
$B#2#4Jq!J#1#2F|J,!K#3#5#0#01_(B
$B5u!a $B$7$_(B $B5uI$N$"$k?M$N$7$_$K(B $BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $B$7$_(B $BBNNO$,$"$j!"2$d$7$b$d$1$d!"$7$_$N$G$-$k?M$K(B $B7K;^h*Nj4]NA(B
$B!J$1$$$7$V$/$j$g$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$B5u!a $B?@7PDK!&4X@aDK(B $B?@7PDK!&4X@aDK$K(B $B7K;^2C[2ImEr!J$1$$$7$+$8$e$D$V$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$BCf!aCf(B $B?@7PDK!&4X@aDK(B $B?'Gr$G!"H/4@$7$d$9$/!"?e$V$H$j$NBN $BKIVa2+fMEr!J$\$&$$$*$&$.$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#5#5#0#01_(B
$B5u!a $B9xDK(B $BHh$l$d$9$/!"8}3i$7!"Lk4VIQG"$"$k$$$OGSG":$Fq$r(B
$BAJ$($k?M$K(B
$BH,L#CO2+4]NA(B
$B!J$O$A$_$8$*$&$,$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#7#5#0#01_(B
$BCf!aCf(B $B9xDK(B $B6ZFy$N$1$$$l$s$rH<$&DK$_$K(B $BgiLt4EApEr!J$7$c$/$d$/$+$s$>$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B6ZFy$N$1$$$l$s$r(B
$BH<$&aVDK(B
$B6ZFy$N$1$$$l$s$rH<$&DK$_$K(B $BgiLt4EApEr!J$7$c$/$d$/$+$s$>$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $BL\$NHh$l(B $BBN $B4c@:HhO+$N?M$K(B $B7K;^2CN59|24iZEr(B
$B!J$1$$$7$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B5u!a $BHh$l!&$@$k$5(B $B@:NO$,8:B`$7!"Lk4VG"$^$?$OG"Mx8:>/$.$_$N?M$K(B $BH,L#CO2+4]NA!J$O$A$_$8$*$&$,$s$j$g$&!K#2#4Jq!J#1#2F|J,!K#3#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#7#5#0#01_(B
$B5u!a $BHh$l!&$@$k$5(B $BC&NO46$,6/$/!"$M$"$;$r$+$/?M$K(B $BJdCf1W5$Er!J$[$A$e$&$($C$-$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$B5u!a $BHh$l!&$@$k$5(B $B0_D2$,C2=ITNI$.$_$N?M$K(B $BO;7/;REr!J$j$C$/$s$7$H$&!K(B
$B#2#4Jq!J#1#2$K$A$V$s!K#4#0#0#01_(B
$B5u!a $BHh$l!&$@$k$5(B $BNd$(>I$GIO7l$N798~$,$"$j!"(B
$B$a$^$$$d$H$-$K9xDK$N$"$k?M$K(B
$BEv5"giLt;6NA(B
$B!J$H$&$-$7$c$/$d$/$5$s$j$g$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#6#5#0#01_(B
$BCf!aCf(B $BHh$l!&$@$k$5(B $B?)M_$,$J$/!"0_ $B>. $B#2#4Jq!J#1#2F|J,!K#4#0#0#01_(B
$B#6#4Jq!J#3#2F|J,!K#1#0#5#0#01_(B
$BCf!aCf(B $BHh$l!&$@$k$5(B $B$H$-$KJ"DK$,$7!"F0X)$d $BH<$&>l9g$NHhO+7qBU$d>.;y5u $B>.7zCfEr(B
$B!J$7$g$&$1$s$A$e$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B>.;y5u $B5u.;y$K(B $B7K;^2CN59|24iZEr(B
$B!J$1$$$7$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $B>.;y5u $BBN $B>.;yLkG">I!"Lk$J$-$K(B $B>.7zCfEr(B
$B!J$7$g$&$1$s$A$e$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $BLkG">I(B $B5u.;y$K(B $B7K;^2CN59|24iZEr(B
$B!J$1$$$7$+$j$e$&$3$D$\$l$$$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BCf!aCf(B $BLkG">I(B $BBN $B>.;yLkG">I!"Lk$J$-$K(B $B>.7zCfEr(B
$B!J$7$g$&$1$s$A$e$&$H$&!K(B
$B#2#4Jq!J#1#2F|J,!K#2#5#0#01_(B
$BFCD'(B $B%D%`%i0lHLMQ4AJ}Lt(B
$B>&IJL>!'(B
$B%D%`%i0lHLMQ4AJ}Lt(B
$B8zG=!&8z2L(B
$B%D%`%i0lHLMQ4AJ}Lt(B
$BJqAu7ABV!'HNGd2A3J!J@G9~!K(B
$BIX?MLt(B $BCf>-Er(B
$B!J$A$e$&$8$g$&$H$&!K(B
$BIX?M=tIB!";:A0;:8e$NIB!"7l$NF;!"99G/4|>c32!"%R%9%F%j!I!"G.46!"B)@Z$l!"F0X)!"$`$/$_5Z$S46KA$K8z$"$j!#(B $B#6B^!J#6F|J,!K#1#0#8#01_(B
$B#1#2B^!J#1#2F|J,!K#1#9#5#01_(B
$B#2#4B^!J#2#4F|J,!K#3#5#1#01_(B
$BIX?MLt(B $BCf>-Er(B
$B!J$A$e$&$8$g$&$H$&!K(B
$B%F%#!<%?%$%W(B
$B@8M}IT=g!"@8M}DK!"F,DK!"8*$3$j!"9xDK!"Nd$(>I!"$N$\$;!"$a$^$$!"B)@Z$l!"F0X)!#(B $B#1#5B^!J#5F|J,!K#8#5#01_(B
$B#3#0B^!J#1#0F|J,!K#1#5#0#01_(B
$BIX?MLt(B $BCf>-Er(B
$B!J$A$e$&$8$g$&$H$&!K(B
$B%i%`!<%k!J>{:^!K(B
$B7l$NF;>I!"Nd$(>I!" $B#2#2#0>{!!#2#2#5#01_(B
$B#4#9#0>{!!#4#0#5#01_(B
$BIX?MLt(B $B%i%`!<%k#Q(B
$B!JIX?MLt!\%S%?%_%s>{:^!K(B
$B99G/4|>c32!"7l$NF;>I!"7n7PIT=g!"Nd$(>I$*$h$S$=$l$i$K?oH<$9$kI!'7n7PDK!"9xDK!"F,DK!"F,=E!"$N$\$;!"8*$3$j!"<*LD$j!"$a$^$$!"F0X)!"B)@Z$l!"ITL2!"%R%9%F%j! $B#1#5#0>{!!#1#5#0#01_(B
$B#3#4#0>{!!#2#7#0#01_(B
$B9-4SF2J#J}(B $B7'g<4](B
$B!J$f$&$?$s$,$s!K(B
$B?)M_IT?6!"!J?)M_8:B`!K!"0_It!&J"ItKDK~46!">C2=ITNI!"0_ $B#1#2Jq!J#1#04]!_#1#2!K#1#0#0#01_(B
$B#3#6Jq!J#1#04]!_#3#6!K#2#6#0#01_(B
$B<"M\(B
$B6/AT(B
$B%D%`%i$N<"M\6/AT:^(B
$B%O%$%/%?%s#D(B
$B<"M\6/AT!"5uc32!&1IM\>c32!&H/G.@->CLW<@45!&G%?1l9g$N1IM\Jd5k(B $B#1K\!J#5#0#m#l!K#1#2#0#01_(B
$B<"M\(B
$B6/AT(B
$BhuB{!J$8$s$8$g$&!K(B $Bl9g$N<"M\6/AT!'5uI!#(B $B#1K\!J#3#0#m#l!K#7#7#71_(B
$B9"$NDK$_!&$O$l$K(B $B%D%`%i4AJ}%H%m!<%A(B
$B5K9
$B0v9"$,$O$l$FDK$`I!'Y(Em1j!"Y(Em<~0O1j!#(B $B#1#88D!J#3F|J,!K#6#5#01_(B
$BJ"It$KHi2<;iKC$,B?$/!"JXHk$,$A$JJ}$K(B $BKIIwDL@;;6(B
$B!J$\$&$U$&$D$&$7$g$&$5$s!K(B
$B%(%-%9pyN3(B
$BJ"It$KHi2<;iKC$,B?$/JXHk$,$A$J$b$N$NI!'9b7l05$N?oH<>I>u!J$I$&$-!"8*$3$j!"$N$\$;!K!"HnK~>I!"$`$/$_!"JXHk!#(B $B#4#8Jq!J#2#4F|J,!K#4#3#0#01_(B
$B9b7lE|$KH<$&HhO+7qBU!"B?0{!&8}3i!#9b7l05$KH<$&$N$\$;!&<*LD$jEy$K(B $BH,L#4]2C2+Gp(B
$B%+%s%]%H%K%/(B
$BHh$l$d$9$/$F!";M;h$,Nd$($d$9$/!"G"0U8:>/$^$?$OB?G"$G8}3i$,$"$j!"0_D25uI!'9b7lE|$KH<$&?oH<>I>u!JHhO+7qBU!"B?0{!"8}3i!K<"M\6/AT!"HhO+2sI|!"2<;hDK!"9xDK!"$7$S$l!"O7?M$N$+$9$_L\!"$+$f$_!"GSG":$Fq!"IQG"!"$`$/$_!"9b7l05$KH<$&?oH<>I>u!J$N$\$;!"8*$3$j!"<*LD$j!"F,DK!"F,=E!"ITL2!"IT0B!K!#(B $B#4#8Jq!J#2#4F|J,!K#4#6#0#01_(B
$B31!"$N$I$NDK$_$K(B $B%+%s%]%"%:%^(B $B0v9"1j!"5$4I;Y1j!"5$4I;YSCB)(B $B#8Jq!J#4F|J,!K#1#2#0#01_(B
$B#1#6Jq!J#8F|J,!K#2#1#0#01_(B
$B$/$9$jEr(B $B%P%9%O!<%V(B $B?@7PDK!"%j%&%^%A!"Nd$(>I!"8*$3$j!"9xDK!"<&!"HhO+2sI|!"9S$l@-!"$"$;$b!"$7$C$7$s!"$R$S!"$"$+$.$l!"$K$-$S!"$?$@$l(B $B%\%H%k!J#6#5#0#m#l!K#3#4#0#01_(B

$BCm0U!K>e5-4AJ}Lt$r#2=54VI~MQ$7$F$b8z2L$KK~B-$G$-$J$$>l9g$O!"Bg;34AJ}$ND49g4AJ}Lt!J%*!<%@!<%a%$%I!K$r$*4+$a$7$^$9!*(B
$BBg;34AJ}F2Lt6I$K!"0lEY!"$*EEOC$/$@$5$$!#(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B


$B!!(B$B!!(B$B!!(B

$B4AJ}$r;n$7$F$_$h$&$H;W$C$?$i(B
$B%D%`%i0lHLMQ4AJ}%(%-%9@=:^(B
$B%P%j%(!<%7%g%s%7%j!<%:(B


$B4AJ}$r=i$a$F$*;n$7$K$J$kJ}$K$b0B?4$J!"#8JqF~$j#4F|J,$N$*;n$7%5%$%:$N4AJ}$+$i!"(B
$B$42HDm$K>oHw$7$40&MQ$$$?$@$1$k(B24$BJqF~$j(B12$BF|J,$d(B
64$BJqF~$j(B32$BF|J,$b$4MQ0U$7$F$*$j$^$9!#(B
$B>I>u$K9g$o$;$F$*A*$S$/$@$5$$!#(B


$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)



$B=w@-$NG:$_$K$*1~$($7$^$9(B
$B%D%`%i$N4AJ}!V=w@-8~$14AJ}!W(B
NEW!



$B!VNd$(>I!W!V99G/4|$N%$%i%$%i!W!V%7%_$,5$$K$J$k!W$J$I!"(B
$B=w@-$KB?$$G:$_$r2~A1$9$k=w@-8~$1$N0{$_$d$9$$>{:^$N4AJ}Lt$G$9!#(B
$B$<$R0lEY$*;n$7$/$@$5$$!#(B

$B!|Ev5"giLt;6NA(B$B!!!!!|2CL#mvt#;6(B$B!!!!!|7K;^h*Nj4]NA(B

$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)



$B%9%H%l%9$d%$%i%$%i(I%$BIT0B$J$I(I%%%(B
$BITL2$G$*G:$_$NJ}$K!*(B
$B%D%`%i$N4AJ}!V


$B!V $B!V$h$/L2$l$J$$!"$@$,?GNE$r
$B!|$B!!!|

$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)


$B!!(B$B!!(B$B!!(B

$B$+$<$r$R$$$?$+$J!)$H;W$C$?$i(B
$B%D%`%i$N4AJ}$+$


$B;R6!$+$iBg?M$^$GI~MQ$7$d$9$$>{:^%7%j!<%:!"(B
1$BF|(B2$B2s$NI~MQ$G(BOK$B!uL2$/$J$i$J$$pyN3%7%j!<%:!"(B
$B8z$-L\$NAa$$%I%j%s%/%?%$%W$NFbI~1U%7%j!<%:$+$i$*A*$S$$$?$@$1$^$9!#(B
$B$9$Y$F>I>uJL$GA*$S$d$9$/$J$C$F$$$^$9!#(B

$B4AJ}pyN3%7%j!<%:(B$B!!!|4AJ}FbI~1U%7%j!<%:(B$B!!!|4AJ}>{:^%7%j!<%:(B$B!!!|3XF8MQ1U:^(B

$BFCJL3d0zM%BT2A3J(B
$B!JA4IJ!"#28D$G#13d0z(B)



$B$*Ld$$9g$o$;$O!"(B
$B4AJ}$r8=BeIB$K3h$+$9!*4AJ}@lLg!!Bg;34AJ}F2Lt6I(B
0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B
$B$^$G!"$*5$7Z$K$*Ld$$9g$o$;$/$@$5$$!#(B


$BBg;34AJ}F2Lt6I(B
$B4AJ}7r9/AjCL%3!<%J!<$X!"%/%j%C%/!*(B




$B:4LnLq=|$1Bg;UDL$j$N4AJ}@lLg!"Bg;34AJ}F2Lt6I!!(BWeb-Page $B$X!"#G#o!*!*!*(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B0eLtIJ$O;HMQ>e$NCm0U$r$*FI$_$$$?$@$-!"@5$7$/$*;H$$$/$@$5$$!#(B
$B$*Gc$$5a$a$N:]$K$O!"4AJ}$r8=BeIB$K3h$+$9(B $B4AJ}@lLg(B $BBg;34AJ}Lt6I$K!"$*5$7Z$K$4AjCL$/$@$5$$!#(B


$B!V%$%s%?!<%M%C%H$G8+$?!*!W(B
$B$H$*OC$/$@$5$$!#(B


$B!JCm0U!K(B
$B4AJ}@lLg!!Bg;34AJ}F2Lt6I$N!!87A*!"4AJ}Lt!"7r9/?)IJ$N$4CmJ8$O!"Bg;34AJ}Lt6I$K!"D>@\!"$*EEOC!"(BFAX$B!"(BE-mail $B$K$F$4MQL?$/$@$5$$!#(B

$B$*EEOC!'(B0283-22-1574$B!"(BFAX$B!'(B0283-22-1607$B!"(BE-mail:ohyama@poem.ocn.ne.jp
$B$*BT$ACW$7$F$*$j$^$9!#(B


$B!VBg;34AJ}F2(B $B4AJ}0e3X$H4AJ}7r9/AjCL!W(B

$B!!!!!!!!!!(B$B!!(B$BBg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B


" THE KAMPO " $B4AJ}(B
$B!!4AJ}Lt(B, How the Japanese Updated Traditional Herbal Medicine


$B!c4AJ}Lt$N$4I~MQ$r$*9M$($N3'MM$X$N$*4j$$!*!d(B

$B!v4AJ}Lt$N$4I~MQ$K4X$7$^$7$F$O!"(B
$B!V;HMQ>e$NCm0U!W$r$h$/FI$_!"!VMQK!!&MQNL!W$r$h$/
$B$^$?!":#2s!";O$a$F!"4AJ}Lt$N$4I~MQ$r4uK>$5$l$k$*5RMM$O!"(B
$B2<5-!"Ld?GI=$KI,MW;v9`$r5-F~$7$FAw?.$9$k$+!"(B

$B4AJ}AjCL$*?=$79~$_%U%)!<%`(B

$B$*EEOC$K$F!"D>@\!"Bg;34AJ}Lt6I$K!"$4AjCL$/$@$5$$!#(B
$B>I>u!&BN\$7$/$*;G$$$7$?>e$G!"E,@Z$J4AJ}Lt$r%"%I%P%$%9$5$;$FD:$-$^$9!#(B

$B!JBg;34AJ}Lt6I(B / $BL5NA4AJ}AjCLEEOC(B $B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4(B / $B#9!'#0#0!A#1#9!'#0#0!K(B

$B!cCm0U!d(B
$BBg;34AJ}Lt6I!"%G%8%?%kE9J^$G!"$*
$B0J>e!"$h$m$7$/$*4j$$CW$7$^$9!#(B

E-mail to Dr. Ohyama Kampo Pharmacy.


$B!!(B$B4AJ}$r8=BeIB$K3h$+$9!*!!4AJ}@lLg!!Bg;34AJ}Lt6I%G%8%?%kE9J^$X!*(B



$BBg;34AJ}F2Lt6I(B $B")(B327-0026$B!!FJLZ8):4Ln;T6b20CgD9D.#2#4#3#2(B
TEL$B!u(BFAX : 0283-22-1574$B!!(B E-mail : ohyama@poem.ocn.ne.jp

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B


$B!!(B$B!!(B$B!!(B

$BIUO?(B
$B!V%D%`%i0eNEMQ4AJ}%(%-%9@=:^!W(B
$BA4IJL\$N2r@b(B


$B4AJ}$r8=BeIB$K3h$+$9!*Bg;34AJ}F2Lt6I(B
Dr. YASUHIRO KOMATSU$B!J(BPh.D$B!K(B & Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
No $B=hJ}L>(B $B-!8zG=!&8z2L!!-";HMQL\I8!a>Z!!-#Lt8z!&LtM}(B $B9=@.@8Lt!&G[9gHf(B
001 $B%D%`%i3k:,Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$C$3$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B<+A3H/4@$,$J$/F,DK!"H/G.!"0-4(!"8*$3$jEy$rH<$&Hf3SE*BNNO$N$"$k$b$N$NI!'46KA!"I!$+$I@-<@45(B($B7kKl1j!"3QKl1j!"Cf<*1j!"Y(EmA#1j!"F}A#1j!"%j%s%QA#1j(B)$B!"8*$3$j!">eH>?H$N?@7PDK!"$8$s$^$7$s(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"1j>I@-$"$k$$$OaVDK@-<@45$N=i4|!"$"$k$$$OK}@-<@45!J8zG=!&8z2L;2>H!K$N5^@-A}0-4|$KMQ$$$k!#(B
$B#1!K46KA$J$I$NG.@-<@45$G$O!"=i4|$G0-4(!"H/G.!"F,DK!"9`GXIt$N$3$o$P$j$J$I$,$"$C$F!"<+A3H/4@$rH<$o$J$$>l9g!#(B
$B#2!KaVDK@-<@45$G$O6I=j$NaVDK!"l9g!#(B
$B#3!K45It$,H/@V!"l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#2!%%$%s%U%k%(%s%6%&%#%k%946@w>I$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%%5%$%H%+%$%s$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x!!%W%m%9%?%0%i%s%8%s#E(B2$B!J#P#G#E(B2$B!K$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%+%C%3%s!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B2.0g
002 $B%D%`%i3k:,Er2C@n5]?I0P(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$C$3$s$H$&$+$;$s$-$e$&$7$s$$(B
$B-!!V8zG=!&8z2L!W(B
$BI!$E$^$j!"C_G?>I!"K}@-I!1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"I!JD!"I!O3!"8eI!O3$J$I$NI!>I>u$rAJ$(!"$3$l$i$N>I>u$,$H$/$KK}@-2=$7$?>l9g$KMQ$$$k!#(B
$B#1!KF,DK!"F,=E!"9`GXIt$N$3$o$P$j$J$I$rH<$&>l9g!#(B

$BF|6I%+%C%3%s!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%7%s%$!D(B2.0g
003 $B%D%`%i25;zEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$D$8$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB>u$,$=$l$[$I7c$7$/$J$/!"BNNO$,Cf0L$G?jI(B:$B%-%l<&!"%$%\<&(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$N<&<@45$G!">I>u$N$"$^$j7c$7$/$J$$$b$N$KMQ$$$k!#(B
$B#1!KJXHk$N798~$N$"$k>l9g!#(B
$B#2!KfjLg$^$?$O1"It$NaVDK$dGBaZ$rH<$&>l9g!#(B
$B#3!K7ZEY$N=P7l$rH<$&>l9g!#(B

$BF|6I%H%&%-!D(B6.0g,$BF|6I%5%$%3!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%^!D(B1.0g,$BF|6I%@%$%*%&!D(B0.5g
005 $B%D%`%i0BCf;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$"$s$A$e$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;7?$GJ"It6ZFy$,CP4K$9$k798~$K$"$j!"0_DK$^$?$OJ"DK$,$"$C$F!"$H$-$K6;$d$1!"$2$C$W!"?)M_IT?6!"$O$-$1$J$I$rH<$&I(B:$B?@7P@-0_1j!"K}@-0_1j!"0_%"%H%K!<(B

$B-"!V;HMQL\I8!a>Z!W(B
$BAi$;7?$GHf3SE*BNNO$NDc2<$7$??M$NK}@-$K7P2a$9$k0_DK$d6;$d$1$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K?)J*$N>C2=$,0-$/!"?4c]ItKDK~46!"0-?4!"SREG$J$I$rAJ$($k>l9g!#(B
$B#2!KJ"It$OFpl9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%(%s%4%5%/!D(B3.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%&%$%-%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%e%/%7%c!D(B1.0g,$B%j%g%&%-%g%&!D(B0.5g
006 $B%D%`%i==L#GTFGEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$&$_$O$$$I$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B2=G?@-HiIf<@45!&5^@-HiIf<@45$N=i4|!"$8$s$^$7$s!"5^@-<>?>!"?eCn(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$NHiIf<@45$G!"45It$O;6H/@-$"$k$$$O!"$S$^$s@-$NH/?>$GJ$$o$l!"^z=P1U$N>/$J$$>l9g$KMQ$$$k!#(B
$B#1!K45It$K2=G?$rH<$&$+$"$k$$$O2=G?$r$/$jJV$9>l9g!#(B
$B#2!K5(O>2l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!J#1!K9%Cf5e3h@-2=:nMQ!J(Bin vitro$B!K(B
$B!J#2!K3h@-;@AG$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!J#3!KHiIf3Q2=$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%-%-%g%&!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%\%/%=%/!D(B3.0g,$B%I%C%+%D!D(B1.5g
007 $B%D%`%iH,L#CO2+4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$A$_$8$*$&$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHhO+!"7qBU46Cx$7$/!"G"Mx8:>/$^$?$OIQ?t!"8}3i$7!"I(B:$B?U1j!"E|G"IB!"1"0`!":A9|?@7PDK!"9xDK!"5S5$!"g/fy%+%?%k!"A0N)A#HnBg!"9b7l05(B

$B-"!V;HMQL\I8!a>Z!W(B
$BCfG/0J9_;~$KO7Npo!JFC$KLk4V$NIQG"!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>eJ"It$KHf$Y$F2l9g!JgA2 $B#2!KB?G"!"IQG"!"K3G"!"GSG"DK$J$I$rH<$&>l9g!#(B
$B#3!KHhO+7qBU46!"9xDK!"8}3i$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%E|G"IBM^@):nMQ!J%i%C%H!K(B
$B#2!%=[4D4o7O$KBP$9$k:nMQ!J%&%5%.!"%^%&%9!K(B
$B#3!%9|Be $B#4!%B$@:5!G=$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#5!%MxG":nMQ!J%i%C%H!K(B
$B#6!%7l059_2<:nMQ!J%i%C%H!K(B
$B#7!%?UB!$KBP$9$k:nMQ!J%i%C%H!K(B
$B#8!%:nMQ5!=x(B
$B!J#1!K%"%k%I!<%9%j%@%/%?!<% $B!J#2!KB$@:5!G=$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%8%*%&!D(B6.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B2.5g,$BF|6I%1%$%R!D(B1.0g,$B=$<#%V%7Kv!D(B0.5g
008 $B%D%`%iBg $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$5$$$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$"$k?M$G!"JXHk$,$A$G!">eJ"It$,D%$C$F6l$7$/!"<*LD$j!"8*$3$j$J$IH<$&$b$N$NI(B:$BC@@P>I!"C@$N$&1j!"2+aU!"4N5!G=>c32!"9b7l05>I!"G>0n7l!"$8$s$^$7$s!"0_;@2aB?>I!"5^@-0_D2%+%?%k!"0-?4!"SREG!"?)M_IT?6!"<&<@!"E|G"IB!"%N%$%m!<%I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!&BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!K0-?4!"SREG!"5(O>It$N6lK~46$J$I$rH<$&>l9g!#(B
$B#2!K8*$3$j!"F,DK!"F,=E!"$a$^$$!"<*LD$j$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32M^@):nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B#2!%4N$N;i $B#3!%C@@P7A@.M^@):nMQ!J%O%`%9%?! $B#4!%93%"%l%k%.!<:nMQ!J%&%5%.!"%i%C%H!"%^%&%9!K(B
$B#5!%=[4D7O$KBP$9$k:nMQ!J%&%5%.!"%i%C%H!"%^%&%9!K(B
$B#6!%:nMQ5!=x(B
$B!J#1!K4N$N;i $B!J#2!K4N$N;i
$BF|6I%5%$%3!D(B6.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%@%$%*%&!D(B1.0g
009 $B%D%`%i>. $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$5$$$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
I.$BBNNOCfEyEY$G>eJ"It$,$O$C$F6l$7$/!"@eB]$r@8$8!"8}CfIT2w!"?)M_IT?6!";~$K$h$jHyG.!"0-?4$J$I$N$"$k$b$N$NI(B:$B=tc32!";:8e2sI|ITA4!!(B
II.$BK}@-4N1j$K$*$1$k4N5!G=>c32$N2~A1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G6;OF6lK~$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KG.@-<@45$G$O?)M_IT?6!"8}CfIT2w46$J$I$rH<$&>l9g!#(B
$B#2!K6;OF6lK~$NG'$a$i$l$k=tH!K(B
$B#3!K?)M_IT?6!"A4?H7qBU46$J$I$rH<$&=tH(B
$B#4!K5u.;y$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32M^@):nMQ!J%i%C%H!K(B
$B#2!%4N7lN.NLDc2 $B#3!%4N:F@8B%?J:nMQ!J%i%C%H!K(B
$B#4!%4N@~0]2=M^@):nMQ!J%i%C%H!K(B
$B#5!%LH1VD4@0:nMQ!J%^%&%9!K(B
$B#6!%LH1VJ#9gBN=|5n:nMQ!J%^%&%9!K(B
$B#7!%93%"%l%k%.!<:nMQ!J%b%k%b%C%H!K(B
$B#8!%931j>I:nMQ!J%i%C%H!K(B
$B#9!%:nMQ5!=x(B
$B!J#1!K4N>c32M^@):nMQ!J(Bin vitro$B!K(B
$B!J#2!K4N@~0]2=M^@):nMQ!J(Bin vitro$B!K(B
$B!J#3!KLH1VD4@0:nMQ!J%i%C%H!"%^%&%9!"(Bin vitro$B!K(B
$B!J#4!K93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B
$B!J#5!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!J#6!K3h@-;@AGM^@):nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,
010 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$1$1$$$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BH/G.4@=P$F!"0-4($7!"?HBNDK$_!"F,DK!"$O$-$1$N$"$k$b$N$NI(B:$B46KA!&N.46!&GY1j!&GY7k3K$J$I$NG.@-<@45!"0_DYag!&==Fs;XD2DYag!&C@$N$&1j!&C@@P!&4N5!G=>c32!&g9B!1j$J$I$N?42
$B-"!V;HMQL\I8!a>Z!W(B
$BG.@-<@45$G$O!"5^@-4|$r7P$F$J$*F,DK!"0-46!"4X@aDK!"?)M_IT?6$J$I$N$"$k>l9g$KMQ$$$k!#K}@-<@45$G$O!"?4c]It$h$j5(O>It$K$+$1$F6lK~46$rAJ$(!"Dq93!&05DK$,G'$a$i$l!J6;OF6lK~!K!"J"D>6Z$NZ;5^$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$N6lK~46!"?)M_IT?6!"J"DK$J$I$rH<$&>l9g!#(B
$B#2!K@:?@IT0B!"ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93DYag:nMQ!J%i%C%H!K(B
$B#2!%4N>c32M^@):nMQ!J%i%C%H!"%^%&%9!K(B
$B#3!%g91jM^@):nMQ!J%i%C%H!K(B
$B#4!%:nMQ5!=x(B
$B!J#1!K93DYag:nMQ!J(Bin vitro$B!K(B
$B!J#2!Kg91jM^@):nMQ!J(Bin vitro$B!K(B
$B!J#3!KLH1VD4@0:nMQ!J(Bin vitro$B!K(B
$B!J#4!K>C2=4I%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!K(B
$B!J#5!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
011 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$1$$$7$+$s$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,I!"IO7l5$L#$G!"F0X)!"B)@Z$l$,$"$j!"?@7P2aIR$N$b$N$NI(B:$B99G/4|>c32!"7l$NF;>I!"?@7P>I!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"4i?'$,$9$0$l$:!"HhO+7qBU46$,$"$j!"F0X)!"B)@Z$l!"ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$h$j5(O>2l9g!#(B
$B#2!K0-4(!"HyG.!"Ep4@!"8}3i$J$I$rH<$&>l9g!#(B

$BF|6I%5%$%3!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%m%3%s!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$B%+%s%-%g%&!D(B2.0g
012 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$+$j$e$&$3$D$\$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"?4X)P6?J!"ITL2!"$$$i$@$AEy$N@:?@>I>u$N$"$k$b$N$NI(B:$B9b7l05>I!"F0L.9E2=>I!"K}@-?UB!IB!"?@7P?jI!"?@7P@-?4X)P6?J>I!"$F$s$+$s!"%R%9%F%j!.;yLkSF>I!"1"0`(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"@:?@IT0B!"ITL2!"$$$i$$$i$J$I$N@:?@?@7P>I>u$,$"$j!"6;OF6lK~$N$"$k>l9g!#(B
$B#1!KF,DK!"F,=E!"8*$3$j$J$I$rH<$&>l9g!#(B
$B#2!KgAK5$KJ"ItBgF0L.$NGoF0$NP6?J$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93F0L.9E2=:nMQ!J%&%5%.!"%i%C%H!K(B
$B#2!%DC@E:nMQ!J%^%&%9!K(B
$B#3!%93a[Z;:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!!!93F0L.9E2=:nMQ!J%^%&%9!"(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%?%$%=%&!D(B2.5g,$BF|6I%K%s%8%s!D(B2.5g,$BF|6I%\%l%$!D(B2.5g,$BF|6I%j%e%&%3%D!D(B2.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
014 $B%D%`%iH>2F_C?4Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$7$c$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$_$>$*$A$,$D$+$(!"$H$-$K0-?4!"SREG$,$"$j?)M_IT?6$GJ"$,LD$C$FFpJX$^$?$O2I(B:$B5^!&K}@-0_D2%+%?%k!"H09Z@-2C2=ITNI!"0_2I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$NKDK~46!"J"CfMkLD$,$"$j!"0-46!"SREG!"2l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"7ZEY$N>eJ"ItDK$J$I$rH<$&>l9g!#(B
$B#2!KIT0B!&ITL2$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!!!0_GS=PB%?J:nMQ(B
$B!LF0J*$G$N:nMQ!M(B
$B!!!!#1!%0_GS=PB%?J:nMQ!J%i%C%H!K(B
$B!!!!#2!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B!!!!#3!%@)EG:nMQ!J%U%'%l%C%H!K(B
$B!!!!#4!%;__C:nMQ!J%i%C%H!"%^%&%9!K(B
$B!!!!#5!%:nMQ5!=x(B
$B!!!!!!!J#1!K0_G4KlKI8f:nMQ!J%i%C%H!K(B
$B!!!!!!!J#2!K931j>I:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!!!!!J#3!KBgD2?eJ,5[<}P6?J:nMQ!J%i%C%H!K(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%+%s%>%&!D(B2.5g,$BF|6I%?%$%=%&!D(B2.5g,$BF|6I%K%s%8%s!D(B2.5g,$BF|6I%*%&%l%s!D(B1.0g,$B%+%s%-%g%&!D(B2.5g
015 $B%D%`%i2+O"2rFGEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$l$s$2$I$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;5$L#$G!"$$$i$$$i$9$k798~$N$"$k$b$N$NI(B:$BS=7l!"EG7l!"2<7l!"G>0n7l!"9b7l05!"?4X)P6?J!"%N%$%m!<%I!"0_1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;5$L#$G4iLL9HD,$7!"@:?@IT0B!"ITL2!"%$%i%$%i$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$NKDK~46$rAJ$($k>l9g!#(B
$B#2!KS=7l!"EG7l!"2<7l$J$I$N=P7l$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%=[4D7O$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B#3!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K7l>.HD6E=8M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%*%&%l%s!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%*%&%P%/!D(B1.5g
016 $B%D%`%iH>2F8|KQEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$3$&$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!"$H$-$KF0X)!"$a$^$$!"SR5$$J$I$rH<$&I!'IT0B?@7P>I!"?@7P@-0_1j!"$D$o$j!"$;$-!"$7$o$,$l@I!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY0J2<$N?M$G!"4i?'$,$9$0$l$:!"?@7P>IE*798~$,$"$j!"0v9"$,:I$,$k46$8!J$$$o$f$k%R%9%F%j!<5e!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K5$J,$,$U$5$.!"ITL2!"F0X)!"@:?@IT0B$J$I$rAJ$($k>l9g!#(B
$B#2!K8F5[:$Fq!"31SV!"6;DK$J$I$rH<$&>l9g!#(B
$B#3!K?4c]It$N?6?e2;$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
017 $B%D%`%i8^Nj;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$l$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B8}3i!"G"NL8:>/$9$k$b$N$NI(B:$BIbI!"=k5$$"$?$j!"E|G"IB(B

$B-"!V;HMQL\I8!a>Z!W(B
$B8}3i$J$i$S$KMxG"8:>/$r $B#1!KIbI>u$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%"%k%3!<%kBe $B#2!%MxG":nMQ!J%i%C%H!K(B
$B#3!%>C2=4I1?F0P6?J:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!MxG":nMQ!J(Bin vitro$B!K(B

$BF|6I%?%/%7%c!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%1%$%R!D(B1.5g
018 $B%D%`%i7K;^2C[2ImEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$8$e$D$V$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BNd$(@-$GHf3SE*BNNO$NDc2<$7$??M$,!";M;h4X@a$NaVDK!"c32$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K4X@aDK$,$"$j!"4(Nd$K$h$jA~0-$9$k>l9g!#(B
$B#2!KHyG.!"Ep4@!"D+$N/$J$I$rAJ$($k>l9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B=$<#%V%7Kv!D(B0.5g
019 $B%D%`%i>.@DN5Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$;$$$j$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
1 $B2<5-<@45$K$*$1$k?eMM$Nab!"?eMMI!=A!"I!JD!"$/$7$c$_!"SCLD!"31SV!"N.N^!!5$4I;YSCB)!"I!1j!"%"%l%k%.!]@-I!1j!"%"%l%k%.!]@-7kKl1j!"46KA!!(B2 $B5$4I;Y1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"SCLD!"31SV!"8F5[:$Fq!"I!>I>u$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KK"Kw?eMM@-$Nab!"?eMM@-I!=A!"$/$7$c$_$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!I:nMQ!J%b%k%b%C%H!"%i%C%H!"(Bin vitro$B!K(B
$B#2!%%&%#%k%946@w$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K%1%_%+%k%a%G%#%(!<%?!<;:@8!&M7N%M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K1j>I:YK&$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%"%;%A%k%3%j%s;I7c$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K%&%#%k%946@w$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%4%_%7!D(B3.0g,$BF|6I%5%$%7%s!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%^%*%&!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
020 $B%D%`%iKI8J2+fMEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$\$&$$$*$&$.$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?'Gr$G6ZFyFp$i$+$/?e$V$H$j$NBN.JXITMx$G2<;h$KIbI!'?U1j!"%M%U%m!<%I!"4X@a1j!"a~!"$;$D!"6Z1j!"IbI!"7n7PIT=g(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7?'Gr$G6ZFy=@$i$+$/!"$$$o$f$k?e$V$H$jBNl9g$KMQ$$$k!#(B
$B#1!KIb/!"4X@a!J$H$/$KI(4X@a!K$Nl9g!#(B

$BF|6I%*%&%.!D(B5.0g,$BF|6I%\%&%$!D(B5.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
021 $B%D%`%i>.H>2F2Ch*NjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$O$s$2$+$V$/$j$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNOCfEyEY$NI(B:$BG%?1SREG(B($B$D$o$j(B)$B!"$=$N$[$+$N=tIB$NSREG(B($B5^@-0_D21j!"<>@-6;Kl1j!"?eI(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"0-?4!"SREG$rl9g$KMQ$$$k!#(B
$B#1!KSREG$O>/$7$:$D2?2s$bEG$-!"EG$$$?8e$b0-?4$N;D$k$h$&$J$b$N$G$"$k!#(B
$B#2!K?4c]It$N$D$+$(46!"$a$^$$!"F0X)$J$I$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
022 $B%D%`%i>CIw;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$U$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BJ,HgJ*$,B?$/!"$+$f$_$N6/$$K}@-$NHiIfIB(B($B<>?>!"i!Kc?>!"?eCn!"$"$;$b!"HiIf$=$&aZ>I(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$NK}@-$NHiIf<@45$G!"45It$KG.46$,$"$C$F!"B?$/$O<>=a$7!"GBaZ$N$O$J$O$@$7$$>l9g$KMQ$$$k!#(B
$B#1!K4h8G$JHi?>$G!"J,HgJ*$,$"$C$FaPHi$r7A@.$7!"$=$N308+$,1xcR$GCOH)$K@VL#$rBS$S!"8}3i$rAJ$($k>l9g!#(B
$B#2!KHiIf$NIBJQ$,2F4|$K$`$+$C$F!"A~0-$9$k798~$N$"$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%R%9%?%_%s:nMQ!J%$%L!K(B
$B#2!%93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K93%R%9%?%_%s:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B
$BF|6I%;%C%3%&!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%=%&%8%e%D!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%b%/%D%&!D(B2.0g,$BF|6I%A%b!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%/%8%s!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$B%4%\%&%7!D(B2.0g,$B%4%^!D(B1.5g,$B%<%s%?%$!D(B1.0g
023 $B%D%`%iEv5"giLt;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$7$c$/$d$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B6ZFy$,0lBN$KFpI!'IO7l!"7qBU46!"99G/4|>c32(B($BF,=E!"F,DK!"$a$^$$!"8*$3$jEy(B)$B!"7n7PIT=g!"7n7P:$Fq!"ITG%>I!"F0X)!"K}@-?U1j!"G%?1Cf$N=tIB(B($BIb?HIT?q!"?4B!J[Kl>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?@.?M=w;R$KMQ$$$i$l$k$3$H$,B?$/!"0lHL$KNd$(>I$GIO7l798~$,$"$j!"@-<~4|$KH<$C$F7PEY$NIbl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!";M;hNd46!"F,DK!"$a$^$$!"<*LD!"8*$3$j!"?4X)P6?J$J$I$N>I>u$rAJ$($k>l9g!#(B
$B#2!KL57n7P!"2aB?7n7P!"7n7P:$Fq$J$I!"7n7P0[>o$N$"$kIX?M!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%GSMqM6H/:nMQ!J%i%C%H!K(B
$B#3!%7l1U6E8G7O$KBP$9$k:nMQ!J%i%C%H!K(B
$B#4!%?UJ]8n:nMQ!J%i%C%H!K(B
$B#5!%99G/4|>c32$KBP$9$k:nMQ!J%^%&%9!K(B
$B#6!%:nMQ5!=x(B
$B!!!J#1!K%[%k%b%s$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K;R5\$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K7l1U6E8G7O$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K%U%j!<%i%8%+%k>C5n:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!J#5!K%"%i%-%I%s;@%+%9%1!<%I$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%/%7%c!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g
024 $B%D%`%i2CL#mvMZ;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$_$7$g$&$h$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BBNI>u!"$H$-$KJXHk$N798~$N$"$kI(B:$BNd$(>I!"5uc32!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*5uI>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K8*$3$j!"F,DK!"$a$^$$!">eH>?H$N<^G.46!"H/:n@-$NH/4@$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It!&5(O>It$K7ZEY$NDq93!&05DK$N$"$k>l9g!#!J6;OF6lK~!K(B
$B#3!K@-<~4|$K4XO"$7$F>e5-@:?@?@7P>I>u$rAJ$($k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%99G/4|>c32$KBP$9$k:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!!!FbJ,Hg7O$X$N:nMQ!J%^%&%9!K(B

$BF|6I%5%$%3!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%\%?%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%O%C%+!D(B1.0g
025 $B%D%`%i7K;^h*Nj4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$V$/$j$g$&$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BBN3J$O$7$C$+$j$7$F$$$F@V$i4i$,B?$/!"J"It$OBgBN=<I(B:$B;R5\JB$S$K$=$NIUB04o$N1j>I!";R5\FbKl1j!"7n7PIT=g!"7n7P:$Fq!"BS2c32(B($BF,DK!"$a$^$$!"$N$\$;!"8*$3$jEy(B)$B!"Nd$(>I!"J"Kl1j!"BGKP>I!"<&<@45!"bP4]1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;$F@V$i4i$N$3$H$,B?$/!"2l9g$KMQ$$$k!#1w7l$KH<$&=t>I>u$KMQ$$$k!#(B
$B#1!KF,DK!"8*$3$j!"$a$^$$!"$N$\$;!"B-$NNd$($J$I$rH<$&>l9g!#(B
$B#2!KL57n7P!"2aB?7n7P!"7n7P:$Fq$J$I7n7P0[>o$N$"$kIX?M!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%[%k%b%s$KBP$9$kD4@a:nMQ!J%i%C%H!K(B
$B#2!%;R5\$KBP$9$k:nMQ!J%^%&%9!K(B
$B#3!%99G/4|>c32$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%H%&%K%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g
026 $B%D%`%i7K;^2CN59|24iZEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$j$e$&$3$D$\$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B2J"6Z$K6[D%$N$"$kHf3SE*BNNO$N?j$($F$$$k$b$N$NI(B:$B>.;yLkG">I!"?@7P?j
$B-"!V;HMQL\I8!a>Z!W(B
$BBNl9g$KMQ$$$k!#(B
$B#1!K1"0`!"0d@:$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#2!K0WHhO+46!"Ep4@!"l9g!#(B
$B#3!KJ"It$,Fpl9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%\%l%$!D(B3.0g,$BF|6I%j%e%&%3%D!D(B3.0,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
027 $B%D%`%iKc2+Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$*$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-4(!"H/G.!"F,DK!"9xDK!"<+A3$K4@$N=P$J$$$b$N$NI(B:$B46KA!"%$%s%U%k%(%s%6(B($B=i4|$N$b$N(B)$B!"4X@a%j%&%^%A!"SCB)!"F};y$NI!JD:I!"S.F}:$Fq(B

$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$+$i>fIW$GBNNO=<l9g$KMQ$$$k!#(B
$B#1!KSCLD!"31SV$J$I$rH<$&>l9g!#(B
$B#2!KF}MD;y$N46KA$G!"I!JD:I$N$"$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%%&%#%k%9A}?#M^@):nMQ!J(Bin vitro$B!K(B
$B#2!%931j>I:nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!KH/G.$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%-%g%&%K%s!D(B5.0g,$BF|6I%^%*%&!D(B5.0,$BF|6I%1%$%R!D(B4.0g,$BF|6I%+%s%>%&!D(B1.5g
028 $B%D%`%i1[U92C[2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$($C$T$+$8$e$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIb.JXITMx$N$"$k$b$N$NI(B:$B?U1j!"%M%U%m!<%I!"<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"Ib/$9$k>l9g$KMQ$$$k!#(B
$B#1!K;M;h4X@a$Nl9g!#(B

$B-#!VLt8z!&LtM}!W(B
$BHiIf1j$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%;%C%3%&!D(B8.0g,$BF|6I%^%*%&!D(B6.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
029 $B%D%`%iG~LgE_Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$P$/$b$s$I$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$Bab$N@Z$l$K$/$$31!"5$4I;Y1j!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J2<$N?M$N7c$7$$31SV$G!"H/:n@-$K31$,IQH/$7$F4iLL9HD,$9$k>l9g$KMQ$$$k!#(B
$B#1!KG4cG$G@Z$l$K$/$$ab$rH<$&>l9g!#(B
$B#2!K0v9"$N4%Ag46$d0cOB46$N$"$k>l9g!#(B
$B#3!K>e5->I>u$rH<$&O7?M$N31SV!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%DC31:nMQ!J%b%k%b%C%H!K(B
$B#2!%5nab:nMQ!J%&%:%i!K(B
$B#3!%5$4I;Y3HD%:nMQ!J%b%k%b%C%H!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K5nab:nMQ!J%&%:%i!"(Bin vitro$B!K(B
$B!!!J#2!K93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B

$BF|6I%P%/%b%s%I%&!D(B10.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$B%3%&%Y%$!D(B5.0g
030 $B%D%`%i??IpEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$V$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?7DDBeI(B:$B0_D2<@45!"0_D25uI!"K}@-D21j!">C2=ITNI!"0_%"%H%K!<>I!"0_2I!"%M%U%m!<%0n7l!"@T?q<@45$K$h$k1?F0$J$i$S$KCN3PKcac!"?@7P?jI!"?4B!J[Kl>I!"?4ITA4$G?4X)P6?J!"H>?HIT?q!"%j%&%^%A!"O7?M@-$=$&aZ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$B?7DDBel9g$KMQ$$$k!#(B
$B#1!KK\J}$N2 $B#2!K$a$^$$!"?HBNF0MI46!"?4X)P6?J$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B7l059_2<:nMQ!J%i%C%H!K(B

$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g,$B=$<#%V%7Kv!D(B0.5g
031 $B%D%`%i8bh%hPEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$e$f$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI(B:$B=,47@-JPF,DK!"=,47@-F,DK!"SREG!"5S5$!">W?4(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"H?I|@-$K5/$3$k7c$7$$F,DK$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K9`$d8*$N$3$j!"SREG$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$KKDK~46!"a]:I46$"$k$$$O?6?e2;$rG'$a$k>l9g!#(B
$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%4%7%e%f!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
032 $B%D%`%i?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO5uI!'5^@-!&K}@-0_D2%+%?%k!"0_%"%H%K!<>I!"0_3HD%!"0-AK(B($B$D$o$j(B)$B!"0`=L?U(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"?)M_IT?6!"0_ItDdBZ46!"2l9g$KMQ$$$k!#(B
$B#1!K0_D25uI>u$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B

$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
033 $B%D%`%iBg2+24C0HiEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$*$&$\$?$s$T$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"2I!'7n7PIT=g!"7n7P:$Fq!"JXHk!"<&<@(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N=<l9g!#(B
$B#1!K7n7P:$Fq!"2aB?7n7P$J$I$N7n7P0[>o$N$"$k>l9g!#(B

$BF|6I%H%&%K%s!D(B4.0g,$BF|6I%\%?%s%T!D(B4.0g,$BF|6I%@%$%*%&!D(B2.0g,$B%H%&%,%7!D(B6.0g,$BL5?e%\%&%7%g%&!D(B1.8
034 $B%D%`%iGr8W2C?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$S$c$C$3$+$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$N3i$-$H$[$F$j$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"BN$,$[$F$j!"8}3i$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KB?G"!"HiIfGBaZ46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!8}3i$KBP$9$k:nMQ!J%i%C%H!K(B

$BF|6I%;%C%3%&!D(B15.0g,$BF|6I%A%b!D(B5.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%K%s%8%s!D(B1.5g,$B%3%&%Y%$!D(B8.0g
035 $B%D%`%i;M5U;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$.$c$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$"$k$b$N$G!"BgZ$H>.Z$H$NCf4V>ZI=$o$9$b$N$NI(B:$BC@G91j!"C@@P>I!"0_1j!"0_;@2aB?!"0_DYag!"I!%+%?%k!"5$4I;Y1j!"?@7P
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"6;OF6lK~!"J"D>6Z$NZ;5^$,$"$j!"%$%i%$%i!"ITL2!"M^$&$D46$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK!"J"ItKDK~46!"F0X)$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93DYag:nMQ!J%i%C%H!K(B
$B#2!%4N!&C@F;>c32M^@):nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x(B
$B!!!J#1!K93DYag:nMQ!J%i%C%H!K(B
$B!!!J#2!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%W%m%H%s%]%s%W3h@-AK32:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g
036 $B%D%`%iLZKIVaEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$b$/$\$&$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4i?'$,$5$($:!"31$r$H$b$J$&8F5[:$Fq$,$"$j!"?4B!2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,!"?4c]It$,$D$+$($F9E$/!"8F5[:$Fq!"Ibl9g$KMQ$$$k!#(B
$B#1!K8}3i!"G"NL8:>/$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B?4ITA4%b%G%k$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%\%&%$!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g
037 $B%D%`%iH>2FGr[2E7KcEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$s$2$S$c$/$8$e$D$F$s$^$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?0_D25uI$G!";}B3@-$N$"$^$j7c$7$/$J$$F,DK!"F,=E46!"$a$^$$$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K0-?4!"SREG!"?)M_IT?6!"A4?H7qBU46$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B
$BF|6I%A%s%T!D(B3.0g,$BF|6I%O%s%2!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%?%/%7%c!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%F%s%^!D(B2.0g,$B%P%/%,!D(B2.0g,$B%+%s%-%g%&!D(B1.0g
038 $B%D%`%iEv5";M5U2C8bh%hP@8U*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$7$.$c$/$+$4$7$e$f$7$g$&$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI!'$7$b$d$1!"F,DK!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$jNd$(>I$GBNl9g$KMQ$$$k!#(B
$B#1!KF,DK!"0-?4!"SREG$J$I$rH<$&>l9g!#(B
$B#2!K2e5-$N>I>u$rDh$9$k>l9g$K$bB?$/MQ$$$i$l$k!#(B

$BF|6I%?%$%=%&!D(B5.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%b%/%D%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%4%7%e%f!D(B2.0g,$BF|6I%5%$%7%s!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
039 $B%D%`%iNj7K[24EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$1$$$8$e$D$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$a$^$$!"$U$i$D$-$,$"$j!"$^$?$OF0X)$,$"$jG"NL$,8:>/$9$k$b$N$NI!'?@7P
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"$a$^$$!"?HBNF0MI46!"$?$A$/$i$_$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KB)@Z$l!"?4X)P6?J!"F,DK!"$N$\$;!"G"NL8:>/$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k>l9g!#(B

$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
040 $B%D%`%iCvNjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BG"NL8:>/!">.JXFq!"8}3i$rAJ$($k$b$N$NI(B:$BG"F;1j!"?UB!1j!"?U@P>I!"NT1j!"GSG"DK!"7lG"!"9x0J2<$NIb
$B-"!V;HMQL\I8!a>Z!W(B
$BIQG"!";DG"46!"GSG"DK!"7lG"$J$I$NGSG">c32$N$"$k>l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%MxG":nMQ!J%i%C%H!K(B
$B#2!%7k@P7A@.M^@):nMQ!J%M%3!"%i%C%H!K(B
$B#3!%93?U1j:nMQ!J%i%C%H!K(B

$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$B%"%-%g%&!D(B3.0g,$B%+%C%;%-!D(B3.0g
041 $B%D%`%iJdCf1W5$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$[$A$e$&$($C$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>C2=5!G=$,?j$(!";M;h7qBU46Cx$7$$5uI(B:$B2F$d$;!"IB8e$NBNNOA}6/!"7k3K>I!"?)M_IT?6!"0_2?HIT?o!"B?4@>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,!"A4?H7qBU46!"?)M_IT?6$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K5uI$J$I$NK}@-<@45$G>e5->I>u$rDh$9$k>l9g!#(B
$B#2!K=Q8e!"IB8e!";:8e$J$I$G?jl9g!#(B
$B#3!K31SV!"HyG.!"Ep4@!"F0X)$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%IB8e$NBNNODc2<$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%9bNp $B#3!%46KA$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!KGr7l5e$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!J#2!KLH1VD4@0:nMQ!J%i%C%H!"%^%&%9!"(Bin vitro$B!K(B
$B!!!J#3!K@:Ac$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%.!D(B4.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%^!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
043 $B%D%`%iO;7/;REr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$C$/$s$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D2$N$*$A$,$D$+$(!"Hh$l$d$9$/!"IO7l@-$GI(B:$B0_1j!"0_%"%H%K!C2=ITNI!"?)M_IT?6!"0_DK!"SREG(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$,0_D25!G=$,Dc2<$7$F!"?)M_IT?6!"?4c]It$NKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"l9g!#(B
$B#2!KJ"JI$N6[D%$,l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!#1!%0_GS=PB%?J:nMQ(B
$B!!#2!%0_G4Kl7lN.NLA}2C:nMQ(B
$B!!#3!%0_G4KlEE0L:9!J(Bpotential difference$B!KDc2 $B!LF0J*$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0P6?J:nMQ!J%$%L!K(B
$B!!#2!%0_E,1~@-CP4K$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!#3!%0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!K(B
$B!!#4!%0_G4Kl7lN.Dc2 $B!!#5!%0_;@!&%Z%W%7%s$NJ,HgM^@):nMQ!J%i%C%H!K(B
$B!!#6!%2CNp$KH<$&>.D2G4Kl$NJQ2=$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!#7!%:nMQ5!=x(B
$B!!!!!J#1!K0_E,1~@-CP4K$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!!!J#2!K0_G4Kl>c32$KBP$9$k:nMQ!J%i%C%H!"(Bin vitro$B!K(B
$B!!!!!J#3!K0_;@!&%Z%W%7%s$NJ,HgM^@):nMQ!J(Bin vitro$B!K(B
$B!!!!!J#4!K3h@-;@AG>C5n:nMQ!J(Bin vitro$B!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
045 $B%D%`%i7K;^Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,?j$($?$H$-$NIw
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$GF,DK!"H/G.!"0-46!"?HBNDK$J$I$,$"$j!"<+A3$K4@$N=P$d$9$$>l9g$KMQ$$$k!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g
046 $B%D%`%i<7J*9_2 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$A$b$D$3$&$+$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?HBN5uI(B:$B9b7l05$KH<$&?oH<>I>u(B($B$N$\$;!"8*$3$j!"<*$J$j!"F,=E(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI$KMQ$$$k!#(B
$B#1!K0WHhO+46!"2?H$NNd$(!"IQG"798~$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B7l059_2<:nMQ!J%i%C%H!K(B

$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%*%&%.!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%*%&%P%/!D(B2.0g,$B%A%g%&%H%&%3%&!D(B3.0g
047 $B%D%`%iD`F#;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$&$H$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BK}@-$KB3$/F,DK$GCfG/0J9_!"$^$?$O9b7l05$N798~$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$?CfG/0J9_$N?M$G!"K}@-$K7P2a$9$kF,DK!"8*$3$j!"$a$^$$$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KD+J}$"$k$$$O$a$6$a;~$KF,DK!"F,=E46$N$"$k$3$H$,B?$$!#(B
$B#2!K$N$\$;!"<*LD!"ITL2!"4c5e7kKl$N=<7l$J$I$rH<$&>l9g!#(B

$BF|6I%;%C%3%&!D(B5.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%O%s%2!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%A%g%&%H%&%3%&!D(B3.0g,$B%-%C%+!D(B2.0g
048 $B%D%`%i==A4BgJdEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$&$<$s$@$$$[$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB8e$NBNNODc2
$B-"!V;HMQL\I8!a>Z!W(B
$BIB8e!"=Q8e$"$k$$$OK}@-<@45$J$I$G!"HhO+?jl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"?)M_IT?6!"4i?'ITNI!"HiIf8OAg!"IO7l$J$I$rH<$&$3$H$,B?$$!#(B
$B#2!KEp4@!"8}Fb4%Ag46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%IB8e$NBNNODc2<$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!% $B#3!%IO7l$KBP$9$k:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!!!!LH1VD4@0:nMQ(B
$B!!!!!!!J#1!K1U@-LH1V$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#2!K:YK&@-LH1V$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#3!K#N#K3h@-$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#4!K%^%/%m%U%!!<%83h@-$KBP$9$k:nMQ!J%^%&%9!K(B
$B!!!!!!!J#5!K%5%$%H%+%$%s;:@8$KBP$9$k:nMQ!J%^%&%9!"(Bin vitro$B!K(B

$BF|6I%*%&%.!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0,$BF|6I%H%&%-!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g
050 $B%D%`%i7U3)O"fKEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$,$$$l$s$.$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BC_G?>I!"K}@-I!1j!"K}@-Y(Em1j!"$K$-$S(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"HiIf$N?'$,@u9u$/!"I{I!9P!"Y(Em$J$I$K1j>I$r5/$3$7$d$9$$>l9g$KMQ$$$k!#(B
$B#1!K4iLL!"0v9"!">e5$F;$J$I$KH/$9$kK}@-$N1j>I@-=t<@45!#(B
$B-#!VLt8z!&LtM}!W(B
$B#1!%936]:nMQ!J(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!K:Bal$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K93%"%l%k%.!<:nMQ!J%^%&%9!K(B
$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%-%-%g%&!D(B1.5g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%1%$%,%$!D(B1.5g,$BF|6I%5%$%3!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g,$BF|6I%8%*%&!D(B1.5g,$BF|6I%7%c%/%d%/!D(B1.5g,$BF|6I%;%s%-%e%&!D(B1.5g,$BF|6I%H%&%-!D(B1.5g,$BF|6I%O%C%+!D(B1.5g,$BF|6I%S%c%/%7!D(B1.5g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%l%s%.%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g
051 $B%D%`%i=aD2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$e$s$A$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$NCP4K@-$^$?$Oa[Z;@-JXHk$KMQ$$$k!#(B
$B#1!KO7?M$"$k$$$O0_D25!G=$NDc2<$7$??M$NJXHk!#(B
$B#2!KHiIf8OAg!"J"JICP4K$7J52t$,?(CN$5$l$k>l9g!#(B

$BF|6I%8%*%&!D(B6.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%H%&%K%s!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%^%7%K%s!D(B2.0g
052 $B%D%`%i0Ugo?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$$$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"Hf3SE*K}@-$K7P2a$9$k;M;h$N4X@a!"6ZFy$NaVDK!"l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B931j>I:nMQ!J%i%C%H!K(B

$BF|6I%h%/%$%K%s!D(B8.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
053 $B%D%`%iAB7P3h7lEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$=$1$$$+$C$1$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK!"9xDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"9xIt$h$j2<;h$K$+$1$F$N6ZFy!"4X@a!"?@7P$,DK$`>l9g$KMQ$$$k!#(B
$B#1!KNd$($K$h$jA}0-$9$k$3$H$,B?$$!#(B
$B#2!K1w7l$rH<$&>l9g!#(B
$BF|6I%7%c%/%d%/!D(B2.5g,$BF|6I%8%*%&!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%=%&%8%e%D!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%H%&%K%s!D(B2.0g,$BF|6I%V%/%j%g%&!D(B2.0g,$BF|6I%4%7%D!D(B1.5g,$BF|6I%A%s%T!D(B1.5g,$BF|6I%\%&%$!D(B1.5g,$BF|6I%\%&%U%&!D(B1.5g,$BF|6I%j%e%&%?%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%S%c%/%7!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%$%l%$%;%s!D(B1.5g,$B%-%g%&%+%D!D(B1.5g
054 $B%D%`%iM^4N;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$+$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$B?@7P>I!"ITL2>I!">.;yLk$J$-!">.;yaQ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?@7P2aIR$G6=J3$7$d$9$/!"E\$j$d$9$$!"%$%i%$%i$9$k!"L2$l$J$$$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$*$A$D$-$,$J$$!"$R$-$D$1!"Lk5c$-$J$I$N$"$k>.;y!#(B
$B#2!K4cb[a[Z;$dl9g!#(B
$B#3!KJ"D>6Z$N6[D%$7$F$$$k>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B93IT0B:nMQ!J%^%&%9!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%A%g%&%H%&%3%&!D(B3.0g
055 $B%D%`%iKc0I4E@PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$-$g$&$+$s$;$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"31SV$,6/$/!"8}3i!"<+A3H/4@!"G.46$J$I$,$"$j!"SCLD!"8F5[:$Fq$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KG4cG$G$d$d@Z$l$K$/$$ab$rH<$&>l9g!#(B
$B#2!K>.;y$KE,MQ$5$l$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%93%"%l%k%.!<:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!!93%"%l%k%.!<:nMQ!J(Bin vitro$B!K(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g
056 $B%D%`%i8^NT;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$j$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BIQG"!"GSG"DK!";DG"46(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$NK}@-$K7P2a$7$?G"O)1j>I$G!"IQG"!"!";DG"46!"GSG"DK$J$I$N$"$k>l9g$KMQ$$$k!#(B
$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%b%/%D%&!D(B3.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$B%+%C%;%-!D(B3.0g
057 $B%D%`%i29@60{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$&$s$;$$$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$N?'$D$d$,0-$/!"$N$\$;$k$b$N$KMQ$$$k(B:$B7n7PIT=g!"7n7P:$Fq!"7l$NF;>I!"99G/4|=}32!"?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"IT0B!"ITL2!"$N$\$;$J$I$N@:?@?@7P>I>u$,$"$j!"=P7l798~$rH<$&>l9g$KMQ$$$k!#(B
$B#1!KHiIf$O2+3l?'$rDh$7!"8OAg$7$F$$$k$3$H$,B?$$!#(B
$B#2!K2<7l$N$"$k>l9g$d!"IX?M$G$O;R5\=P7l$d7n7P2aB?$G=P7l$NB?$$>l9g!#(B
$B#3!KH/G.!"G.46$,$"$C$FGBaZ46$,6/$/!"J,HgJ*$N>/$J$$HiIf>I>u$rH<$&>l9g!#(B
$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g
058 $B%D%`%i@6>eKIIwEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$8$g$&$\$&$U$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$K$-$S(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$N!"4iLL$*$h$SF,It$NH/?>$GH/@V$N6/$$$b$N!"2=G?$7$F$$$k$b$N$J$I$KMQ$$$k!#(B
$B#1!K@DG/
$B-#!VLt8z!&LtM}!W(B
$B#1!%936]:nMQ!J(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!!93%j%Q!<%<:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%-%-%g%&!D(B2.5g,$BF|6I%5%s%7%7!D(B2.5g,$BF|6I%;%s%-%e%&!D(B2.5g,$BF|6I%O%^%\%&%U%&!D(B2.5g,$BF|6I%S%c%/%7!D(B2.5g,$BF|6I%l%s%.%g%&!D(B2.5g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%O%C%+!D(B1.0g
059 $B%D%`%i<#F,al0lJ}(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$B$E$=$&$$$C$]$&(B
$B-!!V8zG=!&8z2L!W(B
$B<>?>!"$/$5!"F}MD;y$N<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$N4iLL!"F,It$J$I$N<>?>$G!"J,HgJ*!"$S$i$s!"aPHi$J$IG'$a!"GBaZ46$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K>.;y$N<>?>$KMQ$$$i$l$k$3$H$,B?$$!#(B
$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%l%s%.%g%&!D(B3.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%1%$%,%$!D(B1.0g,$BF|6I%3%&%+!D(B1.0g,$BF|6I%@%$%*%&!D(B0.5g,$B%K%s%I%&!D(B2.0g
060 $B%D%`%i7K;^2CgiLtEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$7$c$/$d$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJ"ItKDK~46$N$"$kI(B:$B$7$V$jJ"!"J"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J"ItKDK~$7!"J"DK$,$"$j!"N"5^8e=E$rH<$&2l9g$KMQ$$$k!#(B
$BK\J}$O7K;^2CgiLtBg2+Er$h$j$bN"5^8e=E$"$k$$$OJXHk$,7ZEY$N>l9g$K$h$$!#(B
$B#1!KJX0U$r:E$9$,!"2w$/GSJX$7$J$$>l9g!#(B
$B#2!K2<:^I~MQ8e$NJ"DK!#(B
$B#3!K3+J"=Q8e$KJX$,2wDL$7$J$$>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%;__C:nMQ!J%^%&%9!K(B
$B#2!%D24IM"AwG=$KBP$9$k:nMQ!J%^%&%9!K(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
061 $B%D%`%iEm3K>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$+$/$8$g$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;$FJXHk$7$,$A$J$b$N$NI(B:$B7n7PIT=g!"7n7P:$Fq>I!"7n7P;~$d;:8e$N@:?@IT0B!"9xDK!"JXHk!"9b7l05$N?oH<>I>u(B($BF,DK!"$a$^$$!"8*$3$j(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!"BNNO$N=<.J"5^7k!K!"JXHk$7!"$N$\$;$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KF,DK!"$a$^$$!"ITL2!"IT0B!"I>u$rH<$&>l9g!#(B
$B#2!K7n7PIT=g!"7n7P:$Fq$J$I$N$"$kIX?M!#(B

$BF|6I%H%&%K%s!D(B5.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%@%$%*%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BL5?e%\%&%7%g%&!D(B0.9g
062 $B%D%`%iKIIwDL@;;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$\$&$U$&$D$&$7$g$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BJ"It$KHi2<;iKC$,B?$/!"JXHk$,$A$J$b$N$NI(B:$B9b7l05$N?oH<>I>u(B($B$I$&$-!"8*$3$j!"$N$\$;(B)$B!"HnK~>I!"$`$/$_!"JXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N=<l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%HnK~$KBP$9$k:nMQ!J%^%&%9!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!3l?';iKCAH?%$N3h@-2=:nMQ!J%^%&%9!K(B
$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%;%C%3%&!D(B2.0g,$BF|6I%S%c%/%8%e%D!D(B2.0g,$BF|6I%@%$%*%&!D(B1.5g,$BF|6I%1%$%,%$!D(B1.2g,$BF|6I%5%s%7%7!D(B1.2g,$BF|6I%7%c%/%d%/!D(B1.2g,$BF|6I%;%s%-%e%&!D(B1.2g,$BF|6I%H%&%-!D(B1.2g,$BF|6I%O%C%+!D(B1.2g,$BF|6I%\%&%U%&!D(B1.2g,$BF|6I%^%*%&!D(B1.2g,$BF|6I%l%s%.%g%&!D(B1.2g,$BF|6I%7%g%&%-%g%&!D(B0.3g,$B%+%C%;%-!D(B3.0g,$BL5?e%\%&%7%g%&!D(B0.7g
063 $B%D%`%i8^@Q;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$c$/$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BK}@-$K7P2a$7!">I>u$N7c$7$/$J$$I(B:$B0_D21j!"9xDK!"?@7PDK!"4X@aDK!"7n7PDK!"F,DK!"Nd$(>I!"99G/4|=}32!"46KA(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"4(Nd$d<>5$$K?/$5$l$F!"9xDK!"2l9g$KMQ$$$k!#(B
$B#1!KIO7l5$L#$G!">eH>?H$,G.$72?H$NNd$($k>l9g!#(B
$B#2!K7n7PIT=g$d7n7P:$Fq$J$I$N$"$kIX?M!#(B
$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%O%s%2!D(B2.0g,$BF|6I%V%/%j%g%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%-%g%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%1%$%R!D(B1.0g,$BF|6I%3%&%\%/!D(B1.0g,$BF|6I%7%c%/%d%/!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%;%s%-%e%&!D(B1.0g,$BF|6I%?%$%=%&!D(B1.0g,$BF|6I%S%c%/%7!D(B1.0g,$BF|6I%^%*%&!D(B1.0g
064 $B%D%`%i_U4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$c$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNNO$,$*$H$m$($F!"Hh$l$d$9$$$b$N$NF0X)!"B)@Z$l(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"F0X)!"B)@Z$l$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KHiIf$N8OAg!"0WHhO+46!"l9g!#(B
$BF|6I%8%*%&!D(B6.0g,$BF|6I%P%/%b%s%I%&!D(B6.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%^%7%K%s!D(B3.0g,$B%7%c%+%s%>%&!D(B3.0g,$B%"%-%g%&!D(B2.0g
065 $B%D%`%i5"g#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$BIO7l!"ITL2>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K2<7l!"EG7l$J$I$rH<$&>l9g!#(B
$B#2!KEp4@!"A4?H7qBU46!"?)M_IT?6$J$I$rH<$&>l9g!#(B
$BF|6I%*%&%.!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g,$B%5%s%=%&%K%s!D(B3.0g,$B%j%e%&%,%s%K%/!D(B3.0g
066 $B%D%`%i;2AI0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$s$=$$$s(B
$B-!!V8zG=!&8z2L!W(B
$B46KA!"$;$-(B

$B-"!V;HMQL\I8!a>Z!W(B
$B0_D25ul9g$KMQ$$$k!#(B
$B#1!KF,DK!"H/G.!"31SV!"S=ab$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$N$D$+$(!"0-?4!"SREG$J$I$N$"$k>l9g!#(B
$BF|6I%O%s%2!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%C%3%s!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%-%8%D!D(B1.0g,$BF|6I%=%h%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g,$B%<%s%3!D(B2.0g
067 $B%D%`%i=w?@;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$g$7$s$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$N$\$;$H$a$^$$$N$"$k$b$N$NI(B:$B;:A0;:8e$N?@7P>I!"7n7PIT=g!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"$N$\$;$H$a$^$$$,$"$j!"IT0B!"F0X)!"@:?@IT0B!"ITL2!"F,DK$J$I$N@:?@?@7P>I>u$,$"$k>l9g$KMQ$$$k!#(B
$B#1!KK}@-$GB?:L$J>I>u$rAJ$($k>l9g!#(B
$B#2!K@-<~4|$KH<$C$F$"$k$$$O;:A0;:8e$K>I>u$rAJ$($k>l9g!#(B
$BF|6I%3%&%V%7!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%S%s%m%&%8!D(B2.0g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%A%g%&%8!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g
068 $B%D%`%igiLt4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$c$/$d$/$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5^7c$K$*$3$k6ZFy$N$1$$$l$s$rH<$&aVDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$B5^7c$K5/$3$k6ZFy!J$*$b$K2<;h!K$Na[Z;@-aVDK$J$i$S$KJ"ItaMDK$rAJ$($k>l9g$KMQ$$$k!#F\I~$"$k$$$OB>$N=hJ}$HJ;MQ$5$l$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$Ba[=L%b%G%k$K$*$1$k6ZHhO+M^@):nMQ!J%i%C%H!K(B

$BF|6I%+%s%>%&!D(B6.0g,$BF|6I%7%c%/%d%/!D(B6.0g
069 $B%D%`%ih*Nj0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$V$/$j$g$&$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BEG$-$1$d6;$d$1$,$"$jG"NL$,8:>/$9$k$b$N$NI(B:$B0_1j!"0_%"%H%K!
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$G!"0_Fb$K?eJ,$,DdBZ$7$F$$$k$?$a!"0_ItKDK~46!"?4c]It?6?e2;!"6;$d$1!"0-?4$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"?4X)P6?J!"G"Mx8:>/$J$I$rH<$&>l9g!#(B

$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
070 $B%D%`%i9aAI;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$3$&$=$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$j0_D25u $B#1!K?)M_IT?6$d7ZEY$N0-4(!"H/G.$J$I$rH<$&>l9g!#(B
$B#2!K3k:,Er$dKc2+Er$J$I$NKc2+:^$G$O?)M_IT?6$r5/$3$9>l9g!#(B
$BF|6I%3%&%V%7!D(B4.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g
071 $B%D%`%i;MJ*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$b$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$,8OAg$7!"?'$D$d$N0-$$BNc32$N$J$$?M$NI(B:$B;:8e$"$k$$$ON.;:8e$NHhO+2sI|!"7n7PIT=g!"Nd$(>I!"$7$b$d$1!"$7$_!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"l9g$KMQ$$$k!#(B
$B#1!K7n7PIT=g!"<+N'?@7P<:D4>I>u$J$I$rH<$&IX?M!#(B
$B#2!KJ"ItFpl9g!#(B

$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g
072 $B%D%`%i4EG~Bg\'Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$s$P$/$?$$$=$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BLk5c$-!"$R$-$D$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"@:?@6=J3$,$O$J$O$@$7$/!"IT0B!"ITL2!"$R$-$D$1$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"D>6Z$NZ;5^$7$F$$$k>l9g!#(B

$BF|6I%?%$%=%&!D(B6.0g,$BF|6I%+%s%>%&!D(B5.0g,$B%7%g%&%P%/!D(B20.0g
073 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B31!"31$K$h$k6;DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"6/$$31$,=P$F!"ab$,@Z$l$K$/$/!"6;DK$9$k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$h$j5(O>It$K$+$1$F6lK~46$rAJ$(!"Dq93!&05DK$NG'$a$i$l$k>l9g!#!J6;OF6lK~!K(B

$BF|6I%5%$%3!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%+%m%K%s!D(B3.0g
074 $B%D%`%iD40_>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$&$$$8$g$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$NJXHk$KMQ$$$k!#(B
$B#1!KJ"ItKDK~46$,6/$/!"J"DK$7!"JXHk$9$k>l9g!#(B

$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BL5?e%\%&%7%g%&!D(B0.5g
075 $B%D%`%i;M7/;REr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$/$s$7$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;$F4i?'$,0-$/$F!"?)M_$,$J$/!"$D$+$l$d$9$$$b$N$NI(B:$B0_D25u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$,!"0_D25!G=$,Dc2<$7$F!"?)M_IT?6!"?4c]It$NKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"l9g!#(B
$B#2!KJ"JI$N6[D%$,l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%DYag$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%@)EG:nMQ!J%$%L!K(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%K%s%8%s!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%?%$%=%&!D(B1.0g
076 $B%D%`%iN5C@_C4NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$e$&$?$s$7$c$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"2I(B:$BGSG"DK!";DG"46!"G"$NBy$j!"$3$7$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$GHgG"4o!"@8?#4oEy$N1j>I$KH<$C$FGSG"DK!"IQG"!"BS2<$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K5^@-$"$k$$$OK}@-$NHgG"4o!&@8?#4o$N1j>I@-<@45!#(B
$B#2!K1"ItGBaZ46$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%H%&%-!D(B5.0g,$BF|6I%b%/%D%&%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%5%s%7%7!D(B1.0g,$BF|6I%j%e%&%?%s!D(B1.0g
077 $B%D%`%i5]5"g1ghEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$e$&$-$-$g$&$,$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B<&=P7l(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G<&=P7l!"2<7l$J$I$,$"$k>l9g$KMQ$$$k!#(B
$B#1!K=P7l$,D9$S$$$F!"IO7l$d$a$^$$!"l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$B%,%$%h%&!D(B3.0g,$B%"%-%g%&!D(B3.0g
078 $B%D%`%iKc0I0U4EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$-$g$&$h$/$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@aDK!"?@7PDK!"6ZFyDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$,!"=t4X@a$d6ZFy$,l9g$KMQ$$$k!#(B
$B#1!Kl9g!#(B

$BF|6I%h%/%$%K%s!D(B10.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%-%g%&%K%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0
079 $B%D%`%iJ?0_;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$X$$$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B0_$,$b$?$l$F>C2=ITNI$N798~$N$"$kI(B:$B5^!&K}@-0_%+%?%k!"0_%"%H%K!C2=ITNI!"?)M_IT?6(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$,!">C2=>c32$r$-$?$7$F?4c]ItIT2w46!"J"ItKDK~46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K?)M_IT?6!"?)8e$NJ"LD!"2l9g!#(B
$B#2!K2a?)$J$I$K$h$k5^@-0_D2>c32!#(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B0.5g
080 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$3$;$$$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$+$s$N798~$N6/$$798~$N$"$k>.;y$NI(B:$B?@7P>I!"K}@-Y(EmA#1j!"<>?>(B

$B-"!V;HMQL\I8!a>Z!W(B
$BA#IBI!"l9g$KMQ$$$k!#(B
$B#1!K>.;y$KMQ$$$i$l$k$3$H$,B?$$!#(B
$B#2!KaQ$,6/$/!"ITL2!"Lk5c$-$J$I$N$"$k>l9g!#(B
$B#3!KN>J"D>6Z$N6[D%$d!"5(O>2l9g!#(B
$B-#!VLt8z!&LtM}!W(B
$B93%"%l%k%.!<:nMQ!J%^%&%9!K(B

$BF|6I%5%$%3!D(B2.0g,$BF|6I%*%&%4%s!D(B1.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%*%&%l%s!D(B1.5g,$BF|6I%+%m%3%s!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%-%-%g%&!D(B1.5g,$BF|6I%5%s%7%7!D(B1.5g,$BF|6I%8%*%&!D(B1.5g,$BF|6I%7%c%/%d%/!D(B1.5g,$BF|6I%;%s%-%e%&!D(B1.5g,$BF|6I%H%&%-!D(B1.5g,$BF|6I%O%C%+!D(B1.5g,$BF|6I%l%s%.%g%&!D(B1.5g,$B%4%\%&%7!D(B1.5g
081 $B%D%`%iFsDDEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$A$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-?4!"SREG(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G0-?4!"SREG!"0_ItIT2w46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$a$^$$!"F0X)!"F,DK$J$I$rH<$&>l9g!#(B
$B#2!K?4c]It$K?6?e2;$rG'$a$k$3$H$,B?$$!#(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%A%s%T!D(B4.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
082 $B%D%`%i7K;^?M;2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$K$s$8$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_D2$NI(B:$BF,DK!"F0X)!"K}@-0_D21j!"0_%"%H%K!<(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?)M_IT?6!"0-?4!"SREG!"0_ItDdBZ46!"2I>u$KF,DK!"F,=E!"?4X)P6?J$J$I$rH<$&>l9g$KMQ$$$k!#(B
$B#1!KNd$(>I$G4i?'0-$/Hh$l$d$9$$>l9g!#(B

$BF|6I%1%$%R!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B2.0g
083 $B%D%`%iM^4N;62CDDHiH>2F(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$h$/$+$s$5$s$+$A$s$T$O$s$2(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$B?@7P>I!"ITL2>I!">.;yLk$J$-!">.;yaQ>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?@7P2aIR$G6=J3$7$d$9$/!"E\$j$d$9$$!"%$%i%$%i$9$k!"L2$l$J$$$J$I$N@:?@?@7P>I>u$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KM^4N;6$KHf$Y!"$h$jBNNO$,Dc2<$7$F>I>u$,$h$jK}@-2=$7$F$$$k$3$H$,B?$$!#(B
$B#2!K$*$A$D$-$,$J$/!"$R$-$D$1!"Lk5c$-$J$I$N$"$k>.;y!#(B
$B#3!K4cb[a[Z;$dl9g!#(B
$B#4!KJ"D>6Z$N6[D%$7$F$$$k>l9g!#(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%A%g%&%H%&%3%&!D(B3.0g
084 $B%D%`%iBg2+4EApEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$*$&$+$s$>$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$B>o=,JXHk$K9-$/MQ$$$k!#(B

$BF|6I%@%$%*%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g
085 $B%D%`%i?@HkEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$T$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/!"5$4I;Y1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"8F5[:$Fq$rl9g$KMQ$$$k!#(B
$B#1!KSCB)!"31SV$rH<$&$,S=ab$N>/$J$$>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!K%m%$%3%H%j%(%s!J#L#T!K;:@8AK32:nMQ!J(Bin vitro$B!K(B
$B!!!J#2!K931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%^%*%&!D(B5.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%5%$%3!D(B2.0g,$BF|6I%=%h%&!D(B1.5g
086 $B%D%`%iEv5"0{;R(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$$$s$7(B
$B-!!V8zG=!&8z2L!W(B
$BNd$(>I$N$b$N$NI!'K}@-<>?>(B($BJ,HgJ*$N>/$J$$$b$N(B)$B!"$+$f$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$NHiIf<@45$G!"GBaZ$r/$J$$>l9g$KMQ$$$k!#(B
$B#1!KHiIf$,4%Ag$7$F<>=a$7$F$$$J$$>l9g!#(B
$B#2!KO7?M$KE,MQ$5$l$k$3$H$,B?$$!#(B

$BF|6I%H%&%-!D(B5.0g,$BF|6I%8%*%&!D(B4.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%\%&%U%&!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%1%$%,%$!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$B%7%D%j%7!D(B3.0g,$B%+%7%e%&!D(B2.0g
087 $B%D%`%iO;L#4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$m$/$_$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHh$l$d$9$/$FG"NL8:>/$^$?$OB?G"$G!";~$K8}3i$N$"$k$b$N$NI(B:$BGSG":$Fq!"IQG"!"$`$/$_!"$+$f$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"9xDK$*$h$S2<;h$NC&NO46!"$7$S$l$J$I$,$"$j!"G"0UIQ?t!"GSG";~0cOB46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KH,L#CO2+4]!"5ml9g!#(B
$B#2!K>eJ"It$KHf$Y$F2l9g!#(B
$B#3!KHhO+7qBU46!"J"DK$J$I$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g
088 $B%D%`%iFs[2Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$8$e$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B8^==8*(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"8*$d>eOS$,DK$`>l9g$KMQ$$$k!#(B
$BF|6I%O%s%2!D(B4.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%*%&%4%s!D(B2.5g,$BF|6I%3%&%V%7!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%S%c%/%8%e%D!D(B2.5g,$BF|6I%V%/%j%g%&!D(B2.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%$%l%$%;%s!D(B2.5g,$B%F%s%J%s%7%g%&!D(B2.5g,$B%o%-%g%&%+%D!D(B2.5g
089 $B%D%`%i<#BGKP0lJ}(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$@$\$/$$$C$]$&(B
$B-!!V8zG=!&8z2L!W(B
$BBGKP$K$h$k$O$l5Z$SDK$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBGKP!"G1:CEy$G!"45It$,l9g$KMQ$$$k!#(B
$BF|6I%1%$%R!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%;%s%3%D!D(B3.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%@%$%*%&!D(B1.0g,$BF|6I%A%g%&%8!D(B1.0g,$B%\%/%=%/!D(B3.0g
090 $B%D%`%i@6GYEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$O$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$Bab$NB?$/=P$k31(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"G4cG$G@Z$l$K$/$$ab$,B?$/31SV$,A+1d2=$7$?>l9g$KMQ$$$k!#(B
$B#1!K>e5->I>u$,D9$S$$$F0v9"DK!"SN@l9g!#(B
$B#2!KK}@-2=$7$?8F5[4o<@45$Gab$NB?$/=P$k31!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%5nab:nMQ!J%&%5%.!"%O%H!"(Bin vitro$B!K(B
$B#2!%:nMQ5!=x(B
$B!!!J#1!KG41U@~LSM"Aw7O$KBP$9$k:nMQ!J%&%5%.!"(Bin vitro$B!K(B
$B!!!J#2!K3h@-;@AG!"%1%_%+%k%a%G%#%(!<%?!<$KBP$9$k:nMQ(B
$B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J(Bin vitro$B!K(B

$BF|6I%H%&%-!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%&%4%s!D(B2.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%=%&%O%/%R!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%A%/%8%g!D(B2.0g,$B%F%s%b%s%I%&!D(B2.0g,$B%P%$%b!D(B2.0g
091 $B%D%`%iC]G!29C@Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$/$8$g$&$s$?$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B%$%s%U%k%(%s%6!"Iw
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"46KA$J$I$GH/G.$,D9$S$-!"$"$k$$$O2rG.8e!"31$,=P$Fab$,B?$/!"ITL2$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K@:?@IT0B!"?4X)P6?J$J$I$rH<$&>l9g!#(B
$B#2!K5(O>2l9g!J6;OF6lK~!K(B

$BF|6I%O%s%2!D(B5.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%-%-%g%&!D(B2.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%3%&%V%7!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%*%&%l%s!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%K%s%8%s!D(B1.0g,$B%A%/%8%g!D(B3.0g
092 $B%D%`%i<"1";jJuEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$$$s$7$[$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$,Dc2<$7$??M$NK}@-$K7P2a$7$?31SV$KMQ$$$k!#(B
$B#1!KHf3SE*@Z$l$d$9$$ab$G!"NL$N$5$[$IB?$/$J$$>l9g!#(B
$B#2!K?)M_IT?6!"A4?H7qBU46!"Ep4@$J$I$rH<$&>l9g!#(B
$B#3!K8F5[4o<@45$,D9$S$$$?>l9g$N$;$-!&$?$s!#(B
$BF|6I%3%&%V%7!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%P%/%b%s%I%&!D(B3.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%O%C%+!D(B1.0g,$B%8%C%3%T!D(B3.0g,$B%P%$%b!D(B2.0g
093 $B%D%`%i<"1"9_2PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$8$$$s$3$&$+$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$K$&$k$*$$$,$J$/ab$N=P$J$/$F31$3$`$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNODc2<$7$??M$G!"HiIf$N?'$,@u9u$/!"31SV!"G4cG$G@Z$l$K$/$$ab$J$I$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KMl9g!#(B
$B#2!KO7?M$d5ul9g!#(B
$B#3!K8F5[4o<@45$,D9$S$$$?>l9g!#(B

$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%8%*%&!D(B2.5g,$BF|6I%7%c%/%d%/!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%H%&%-!D(B2.5g,$BF|6I%P%/%b%s%I%&!D(B2.5g,$BF|6I%*%&%P%/!D(B1.5g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%A%b!D(B1.5g,$B%F%s%b%s%I%&!D(B2.5g
095 $B%D%`%i8^8WEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$3$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$;$-!"5$4I;Y$<$s$=$/(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!"SCLD!"7c$7$$31SV$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K0-46!"H/G.$O$J$/!"<+A3H/4@!"8}3i$rAJ$($k>l9g!#(B
$B#2!K>.;y$KIQMQ$5$l$k!#(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%^%*%&!D(B4.0g,$BF|6I%=%&%O%/%R!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g
096 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!";~$KF0X)!"$a$^$$!"SR5$$J$I$rH<$&I(B:$B>.;y$<$s$=$/!"5$4I;Y$<$s$=$/!"5$4I;Y1j!"$;$-!"IT0B?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"7ZEY$N6;OF6lK~!"?4c]It$NKDK~46$,$"$j!"31SV!"SCLD!"@:?@IT0B!"M^$&$D798~!"?)M_IT?6!"A4?H7qBU46$J$I$rAJ$($k>l9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%b%k%b%C%H!"(Bin vitro$B!K(B
$B#2!%5$F;G4Kl@~LSM"Aw$N2~A1:nMQ!J(Bin vitro$B!K(B
$B#3!%93IT0B:nMQ!J%^%&%9!K(B
$B#4!%:nMQ5!=x(B
$B!!!J#1!K%1%_%+%k%a%G%#%(!<%?!<$N;:@8!&M7N%M^@):nMQ!J(Bin vitro$B!!!!!!!!!!!K(B
$B!!!J#2!K#I#g#E;:@8M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#3!K%5%$%H%+%$%s;:@8$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#4!K9%;@5e$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#5!K#N#O;:@8$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!!J#6!K@\CeJ,;RH/8=M^@):nMQ!J(Bin vitro$B!K(B
$B!!!J#7!K%9%F%m%$%I
$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
097 $B%D%`%iBgKIIwEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$\$&$U$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B4X@a$,$O$l$FDK$_!"Kcac!"6/D>$7$F6~?-$7$,$?$$$b$N$NI(B:$B2<;h$NK}@-4X@a%j%&%^%A!"K}@-4X@a1j!"DKIw(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"4i?'$,0-$/!"4X@a$Nc32$J$I$,$"$j!"0lHL$K$3$l$i$N>I>u$,K}@-$K7P2a$7$?>l9g$KMQ$$$i$l$k!#(B
$BF|6I%*%&%.!D(B3.0g,$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%\%&%U%&!D(B3.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%4%7%D!D(B1.5g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%K%s%8%s!D(B1.5g,$B%-%g%&%+%D!D(B1.5g,$B%H%A%e%&!D(B3.0g,$B%+%s%-%g%&!D(B1.0g,$B=$<#%V%7Kv!D(B1.0g
098 $B%D%`%i2+fM7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$.$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?HBN5uI(B:$B5u
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"HhO+7qBU46$,Cx$7$/!"Ep4@$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK!"?)M_IT?6!"B)@Z$l$J$I$rH<$&>l9g!#(B
$B#2!KH/?>!"$S$i$s$J$I$NHiIf>I>u$rH<$&>l9g!#(B
$B#3!KAO=}<#L~$NA+1d2=$dK}@-2=G?Ac$N$"$k>l9g!#(B
$B#4!KJ"It$OJ"JI$,Gv$/J"D>6Z$,6[D%$7$F$$$k>l9g!#(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%*%&%.!D(B4.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
099 $B%D%`%i>.7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BBNI(B:$B>.;y5u.;yLkG">I!"Lk$J$-(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN6Z$N6[D%$9$k>l9g$KMQ$$$k!#(B
$B#1!KJ"DK$rH<$&>l9g!#(B
$B#2!K?4X)P6?J!"Ep4@!";M;h7qBU46$J$I$rH<$&>l9g!#(B
$B#3!K5u
$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
100 $B%D%`%iBg7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BJ"$,Nd$($FDK$_!"J"ItKDK~46$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$,Dc2<$7$??M$G;M;h$dJ"It$,Nd$(!"J"DK!"J"ItKDK~!"8]D2$N$"$k>l9g$KMQ$$$k!#(B
$B#1!KJ"JI$,$&$9$/Fpl9g!#(B
$B#2!KNd$($K$h$j>I>u$N0-2=$9$k>l9g!#(B
$B#3!K3+J"=Q8e$ND24IDL2a>c32$KH<$&J"DK!"J"ItKDK~46!#(B

$B-#!VLt8z!&LtM}!W(B
$B!L%R%H$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0B%?J:nMQ(B
$B!!#2!%>C2=4I%[%k%b%s$KBP$9$k:nMQ(B
$B!LF0J*$G$N:nMQ!M(B
$B!!#1!%>C2=4I1?F0B%?J:nMQ!J%$%L!K(B
$B!!#2!%%$%l%&%92~A1:nMQ!J%i%C%H!"%^%&%9!K(B
$B!!#3!%>C2=4I5!G=0[>o2~A1:nMQ!J%i%C%H!K(B
$B!!#4!%:nMQ5!=x(B
$B!!!!!J#1!K>C2=4I1?F0B%?J:nMQ!J(Bin vitro$B!K(B
$B!!!!!J#2!K%7%/%m%*%-%7%2%J!<% $B!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J(Bin vitro$B!K(B

$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%5%s%7%g%&!D(B2.0g,$B%+%s%-%g%&!D(B5.0g
101 $B%D%`%i>#Kc3k:,Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$^$+$C$3$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B46KA$N=i4|!"HiIf1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$B46KA$N=i4|!"HiIf1j$KMQ$$$k!#(B
$B#1!KF,DK!"H/G.!"0-46$J$I$rH<$&>l9g!#(B
$B#2!KKc?>$J$IH/?>$rH<$&>l9g!#(B

$BF|6I%+%C%3%s!D(B5.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%7%g%&%^!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B0.5g
102 $B%D%`%iEv5"Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BGXCf$K4(Nd$r3P$(!"J"ItKDK~46$dJ"DK$N$"$k$b$N(B

$B-"!V;HMQL\I8!a>Z!W(B
$BNd$(>I$G7l?'$N0-$$Hf3SE*BNNO$NDc2<$7$??M$G!"6;J"It(B
$B$h$jGXIt$K$+$1$F!"aVDK$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K69?4>IMM!"O>4V?@7PDKMM$NDK$_$,$"$k>l9g!#(B
$BF|6I%H%&%-!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%5%s%7%g%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$B%+%s%-%g%&!D(B1.5g
103 $B%D%`%i;@\'?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$=$&$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?4?H$,$D$+$l
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"?4?H$H$b$KHhO+$7$F!"ITL2$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KK}@-<@4545l9g!#(B
$B#2!K@:?@IT0B!"?@7P2aIR$J$I$rH<$&>l9g!#(B

$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%+%s%>%&!D(B1.0g,$B%5%s%=%&%K%s!D(B10.0g
104 $B%D%`%i?I0P@6GYEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$s$$$;$$$O$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI!$E$^$j!"K}@-I!1j!"C_G?>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"G?@-I!O3!"8eI!O3$J$I$rH<$&I!<@45$KMQ$$$k!#(B
$B#1!K45It$KG.465Z$SaVDK$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!931j>I:nMQ!J(Bin vitro$B!K(B

$BF|6I%;%C%3%&!D(B5.0g,$BF|6I%P%/%b%s%I%&!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%5%s%7%7!D(B3.0g,$BF|6I%A%b!D(B3.0g,$BF|6I%7%g%&%^!D(B1.0g,$B%S%c%/%4%&!D(B3.0g,$B%7%s%$!D(B2.0g,$B%S%o%h%&!D(B2.0g,
105 $B%D%`%iDLF3;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$D$&$I$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j2I(B:$B7n7PIT=g!"7n7PDK!"99G/4|=}32!"9xDK!"JXHk!"BG$A?H(B($BBGKP(B)$B!"9b7l05$N?oH<>I>u(B($BF,DK!"$a$^$$!"8*$3$j(B)

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!"BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!KEm3K>55$Er$KHf$Y!"@:?@?@7P>I>u$,$h$j7c$7$$>l9g!#(B
$B#2!KF,DK!"$N$\$;!"ITL2!"IT0B$J$I$N@:?@?@7P>I>u$rH<$&>l9g!#(B
$B#3!K7n7PIT=g!"7n7P:$Fq>I$J$I$N$"$kIX?M!#(B

$BF|6I%-%8%D!D(B3.0g,$BF|6I%@%$%*%&!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%3%&%+!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%b%/%D%&!D(B2.0g,$B%=%\%/!D(B2.0g,$BL5?e%\%&%7%g%&!D(B1.8g
106 $B%D%`%i297PEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$&$s$1$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BI(B:$B7n7PIT=g!"7n7P:$Fq!"$3$7$1!"99G/4|=}32!"ITL2!"?@7P>I!"<>?>!"B-9x$NNd$(!"$7$b$d$1(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$?Nd$(>I$N?M$G!"8$N$[$F$j!"8}?0$N4%Ag!"2l9g$KMQ$$$k!#(B
$B#1!K@-4o=P7l!"7n7P0[>o!"ITG%$J$I$N$"$kIX?M!#(B
$B#2!K>e5->I>u$O!"@-<~4|$K4XO"$7$F>CD9$9$k$3$H$,B?$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%GSMqM6H/:nMQ!J%i%C%H!K(B
$B#2!%:nMQ5!=x(B
$B!!!!!!!!%[%k%b%s$KBP$9$k:nMQ!J%i%C%H!"(Bin vitro$B!K(B

$BF|6I%P%/%b%s%I%&!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%;%s%-%e%&!D(B2.0g,$BF|6I%K%s%8%s!D(B2.0g,$BF|6I%\%?%s%T!D(B2.0g,$BF|6I%4%7%e%f!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$B%"%-%g%&!D(B2.0g
107 $B%D%`%i5m $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$4$7$c$8$s$-$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BHh$l$d$9$/$F!";M;h$,Nd$($d$9$/G"NL8:>/$^$?$OB?G"$G;~$K8}3i$,$"$kI(B:$B2<;hDK!"9xDK!"$7$S$l!"O7?M$N$+$9$_L\!"$+$f$_!"GSG":$Fq!"IQG"!"$`$/$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$"$k$$$OO7?M$G9xIt$*$h$S2<;h$NC&NO46!"Nd$(!"$7$S$l$J$I$,$"$j!"GSG"$N0[>o!JFC$KLk4V$NIQG"!K$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>eJ"It$K$/$i$Y$F2l9g!JgA2 $B#2!KB?G"!"IQG"!"K3G"!"GSG"DK$J$I$rH<$&>l9g!#(B
$B#3!KHhO+7qBU46!"9xDK!"8}3i$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%?e>=BN:.By$KBP$9$k:nMQ!J%i%C%H!K(B
$B#2!%?@7PEAF3B.EY$KBP$9$k:nMQ!J%i%C%H!K(B
$B#3!%93?/32 $B#4!%7lN.NLA}2C:nMQ!J%i%C%H!K(B
$B#5!%:nMQ5!=x(B
$B!!#1!K?e>=BN:.By$KBP$9$k:nMQ!J(Bin vitro$B!K(B
$B!!#2!K93?/32 $B!!#3!K7lN.NLA}2C:nMQ!J%i%C%H!K(B

$BF|6I%8%*%&!D(B5.0g,$BF|6I%4%7%D!D(B3.0g,$BF|6I%5%s%7%e%f!D(B3.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%\%?%s%T!D(B3.0g,$BF|6I%1%$%R!D(B1.0g,$B=$<#%V%7Kv!D(B1.0g
108 $B%D%`%i?M;2M\1IEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$K$s$8$s$h$&$($$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIB8e$NBNNODc2
$B-"!V;HMQL\I8!a>Z!W(B
$BIB8e!&=Q8e$"$k$$$OK}@-<@45$J$I$GHhO+?jl9g$KMQ$$$k!#(B
$B#1!KA4?H7qBU46!"4i?'ITNI!"?)M_IT?6$J$I$rH<$&$3$H$,B?$$!#(B
$B#2!KK}@-<@45$G!"HyG.!"0-46!"31SV$J$I$rH<$&>l9g!#(B

$BF|6I%8%*%&!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%S%c%/%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%1%$%R!D(B2.5g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%*%&%.!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g
109 $B%D%`%i>. $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$7$g$&$5$$$3$H$&$+$-$-$g$&$;$C$3$&(B
$B-!!V8zG=!&8z2L!W(B
$B0v9"$,$O$l$FDK$`I!'Y(Em1j!"Y(Em<~0O1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"HyG.$,$"$j!"?4c]It$h$j5(O>It$K$+$1$F$N6lK~46!"05Gw46!J6;OF6lK~!K!"?)M_IT?6$J$I$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K>e5$F;$N0!5^@-$J$$$7K}@-$N1j>I@-<@45!#(B

$BF|6I%;%C%3%&!D(B10.0g,$BF|6I%5%$%3!D(B7.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%-%-%g%&!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
110 $B%D%`%iN)8z;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$C$3$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$BH4;u8e$NaVDK!";uDK(B

$B-"!V;HMQL\I8!a>Z!W(B
$B;uDK!";u:,DK$*$h$S8}9PFb$N
$BF|6I%5%$%7%s!D(B2.0g,$BF|6I%7%g%&%^!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$BF|6I%j%e%&%?%s!D(B1.0g
111 $B%D%`%i@6?4O!;R0{(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$7$s$l$s$7$$$s(B
$B-!!V8zG=!&8z2L!W(B
$BA4?H7qBU46$,$"$j!"8}$d@e$,4%$-!"G"$,=P$7$V$k$b$N$NI(B:$B;DG"46!"IQG"!"GSG"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BJ?AG$h$j0_D25ul9g$KMQ$$$k!#(B
$B#1!KNd$(>I$G?@7P $B#2!KK}@-$NHgG"4o<@45$KH<$&>l9g!#(B

$BF|6I%P%/%b%s%I%&!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%7%c%<%s%7!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%*%&%.!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%l%s%K%/!D(B4.0g,$B%8%3%C%T!D(B2.0g
112 $B%D%`%iCvNjEr9g;MJ*Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$A$g$l$$$H$&$4$&$7$b$D$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHiIf$,8OAg$7!"?'$D$d$N0-$$BNc32$N$J$$?M$NI(B:$BGSG":$Fq!"GSG"DK!";DG"46!"IQG"(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$G!"IQG"!";DG"46!"GSG"DK$J$I$NGSG">c32$,K}@-2=$7$?$j!"H?I|$7$F5/$3$k>l9g$KMQ$$$k!#(B
$BF|6I%8%*%&!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%?%/%7%c!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$B%"%-%g%&!D(B3.0g,$B%+%C%;%-!D(B3.0g
113 $B%D%`%i;02+_C?4Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$*$&$7$c$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!"$N$\$;5$L#$G!"4iLL9HD,$7!"@:?@IT0B$G!"JXHk$N798~$N$"$k$b$N$NI(B:$B9b7l05$N?oH<>I>u(B($B$N$\$;!"8*$3$j!"<*$J$j!"F,=E!"ITL2!"IT0B(B)$B!"I!7l!"<&=P7l!"JXHk!"99G/4|=}32!"7l$NF;>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBN3J!&BNNO$H$b$K=<l9g$KMQ$$$k!#(B
$B#1!K5$J,$,$$$i$$$i$7$FMn$ACe$+$:!"@:?@IT0B$dITL2$rAJ$($k>l9g!#(B
$B#2!K?4c]It$NKDK~46$rAJ$($k>l9g!#(B
$B#3!KI!=P7l!"2<7l$J$I$N$"$k>l9g!#$?$@$7!"=P7l$,D9$S$$$FIO7l$NCx$7$$>l9g$K$OMQ$$$J$$!#(B

$B-#!VLt8z!&LtM}!W(B
$B:nMQ5!=x(B
$B!!!!#1!%7l059_2<:nMQ!J(Bin vitro$B!K(B
$B!!!!#2!%Cf?u?@7P7O$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%*%&%l%s!D(B3.0g,$BF|6I%@%$%*%&!D(B3.0g
114 $B%D%`%i $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$$$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BEG$-5$!"?)M_IT?6!"$N$I$N$+$o$-!"GSG"$,>/$J$$$J$I$NI!'?e_C@-2
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$h$j5(O>It$K$+$1$F$N6lK~46!"$J$i$S$KDq93!&05DK!J6;OF6lK~!K$,$"$j!"G"NL8:>/!"Ibl9g$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%MxG":nMQ!J%i%C%H!K(B
$B#2!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#3!%:nMQ5!=x(B
$B!!!!!!MxG":nMQ!J(Bin vitro$B!K(B

$BF|6I%5%$%3!D(B7.0g,$BF|6I%?%/%7%c!D(B5.0g,$BF|6I%O%s%2!D(B5.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%A%g%l%$!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
115 $B%D%`%i0_NjEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$l$$$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B?e_C@-$N2/$rH<$&I(B:$B?)$"$?$j!"=k5$$"$?$j!"Nd$(J"!"5^@-0_D21j!"J"DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"?4c]It$K?6?e2;$rG'$a!"?eMM@-$N2l9g$KMQ$$$k!#(B
$B#1!KJ"ItKDK~46!"7ZEY$NJ"DK!"G"NL8:>/$J$I$rH<$&>l9g!#(B
$BF|6I%3%&%\%/!D(B2.5g,$BF|6I%=%&%8%e%D!D(B2.5g,$BF|6I%?%/%7%c!D(B2.5g,$BF|6I%A%g%l%$!D(B2.5g,$BF|6I%A%s%T!D(B2.5g,$BF|6I%S%c%/%8%e%D!D(B2.5g,$BF|6I%V%/%j%g%&!D(B2.5g,$BF|6I%1%$%R!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.5g,$BF|6I%?%$%=%&!D(B1.5g,$BF|6I%+%s%>%&!D(B1.0g
116 $B%D%`%ih*Nj0{9gH>2F8|KQEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$V$/$j$g$&$$$s$4$&$O$s$2$3$&$\$/$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5$J,$,$U$5$$$G!"0v9"!"?)F;It$K0[J*46$,$"$j!";~$KF0X)!"$a$^$$!"SR5$!"6;$d$1$J$I$,$"$j!"G"NL$N8:>/$9$k$b$N$NI(B:$BIT0B?@7P>I!"?@7P@-0_1j!"$D$o$j!"N/0{!"0_1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$G!"M^$&$D>uBV$rDh$7!"0v9"It$N0[J*46!"0_ItKDK~46$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!K$a$^$$!"F0X)!"0-?4!"?4c]It?6?e2;$J$I$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%V%/%j%g%&!D(B5.0g,$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%3%&%\%/!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%=%h%&!D(B2.0g,$BF|6I%-%8%D!D(B1.5g,$BF|6I%7%g%&%-%g%&!D(B1.0g$B!!(B
117 $B%D%`%ih!DD8^Nj;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$s$A$s$4$l$$$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$N$I$,3i$$$F!"G"$,>/$J$$$b$N$NI(B:$BSREG!"$8$s$^$7$s!"FsF|?l$N$`$+$D$-!"$`$/$_(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$N?M$G!"8}3i!"G"NL8:>/!"Ibl9g$KMQ$$$k!#(B

$BF|6I%?%/%7%c!D(B6.0g,$BF|6I%=%&%8%e%D!D(B4.5g,$BF|6I%A%g%l%$!D(B4.5g,$BF|6I%V%/%j%g%&!D(B4.5g,$BF|6I%1%$%R!D(B2.5g,$B%$%s%A%s%3%&!D(B4.0g
118 $B%D%`%iNjU*[24EEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$-$g$&$8$e$D$+$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B9x$KNd$($HDK$_$,$"$C$F!"G"NL$,B?$$I(B:$B9xDK!"9x$NNd$(!"LkG">I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7$??M$G!"9xIt$h$j2<;h$K$+$1$F$NNd$($,82Cx$G!"IQG"$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KNd$($N$?$a$K9x2<;h$KaVDK$rAJ$($k$3$H$b$"$k!#(B

$BF|6I%V%/%j%g%&!D(B6.0g,$BF|6I%S%c%/%8%e%D!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$B%+%s%-%g%&!D(B3.0g
119 $B%D%`%iNj4EU*L#?I2F?NEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$j$g$&$+$s$-$g$&$_$7$s$2$K$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BIO7l!"Nd$(>I$GSCLD$rH<$&S=ab$NB?$$31SV2j$"$k$b$N!#5$4I;Y1j!"5$4I;YSCB)!"?4B!?j
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$,Dc2<$7!"Nd$(>I$GIO7l798~$K$"$k?M$N!"SCLD!"31SV!"S=ab!"?eMM@-I!=A$J$I$rDh$9$k>l9g$KMQ$$$k!#(B
$B#1!K0_D25uc32$J$I$rDh$9$k>l9g!#(B
$B#2!KHhO+7qBU46!"F0X)!"B)@Z$l!"Ibl9g!#(B
$B#3!KJ"It$,Fpl9g!#(B

$BF|6I%-%g%&%K%s!D(B4.0g,$BF|6I%O%s%2!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%4%_%7!D(B3.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%5%$%7%s!D(B2.0g,$B%+%s%-%g%&!D(B2.0g
120 $B%D%`%i2+O"Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$*$&$l$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0_It$NDdBZ46$d=E0546!"?)M_IT?6$N$"$k$b$N$NI(B:$B5^@-0_1j!"FsF|?l!"8}Fb1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY0J>e$N?M$G!">eJ"ItDK!"0-?4!"SREG$,$"$j!"?4c]It$KDq93$NG'$a$i$l$k>l9g$KMQ$$$k!#(B
$B#1!K?4c]It$NDdBZ46$d=E0546!"?)M_IT?6$J$I$rH<$&>l9g!#(B
$B#2!K@e$K2+?'B]!"Kt$OGrB]$,$"$j!"8}=-$rH<$&>l9g!#(B

$BF|6I%O%s%2!D(B6.0g,$BF|6I%*%&%l%s!D(B3.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%1%$%R!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$B%+%s%-%g%&!D(B3.0g
121 $B%D%`%i;0J*2+:#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$5$s$b$D$*$&$4$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$=$l0J>e$N?M$G!"l9g$KMQ$$$k!#(B
$B#1!Kl9g!#(B
$B#2!K8}3i$rH<$&>l9g!#(B
$B#3!K8!"B-m($NG.46!"GBaZ46!"4%Ag!"H/@V$J$I$rH<$&>l9g!#(B
$BF|6I%8%*%&!D(B6.0g,$BF|6I%*%&%4%s!D(B3.0g,$BF|6I%/%8%s!D(B3.0g
122 $B%D%`%iGSG?;65ZEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$O$$$N$&$5$s$-$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B45It$,H/@V!"I!"ag!"$;$D!"LLD#!"$=$NB>$;$D

I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEYA08e$N?M$N2=G?@-HiIf<@455Z$S;uAeG?O3!";u:,1j$J$I$KMQ$$$k!#(B

$BF|6I%-%-%g%&!D(B4.0g,$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%-%8%D!D(B3.0g,$BF|6I%7%c%/%d%/!D(B3.0g,$BF|6I%?%$%=%&!D(B3.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
123 $B%D%`%iEv5"7zCfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$H$&$-$1$s$A$e$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHhO+$7$d$9$/!"7l?'$N$9$0$l$J$$$b$N$NI(B:$B7n7PDK!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$NDc2<$7$??M$G!"HhO+$7$d$9$/!"4i?'ITNI!"l9g$KMQ$$$k!#(B
$B#1!K@-4o=P7l!"<&=P7l$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,FpB&$NJ"D>6Z$,Z;5^$7$F$$$k>l9g!#(B
$B#3!Ke5->I>u$r;}$DIX?M$KMQ$$$i$l$k!#(B

$BF|6I%7%c%/%d%/!D(B5.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%H%&%-!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
124 $B%D%`%i@n5]CcD4;6(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$s$-$e$&$A$c$A$g$&$5$s(B
$B-!!V8zG=!&8z2L!W(B
$B$+$I!"F,DK(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N6/ $B#1!K46KA$G$O=i4|$G!"F,DK$NB>!"0-46!"H/G.!"4X@aDK$J$I$N$"$k>l9g!#(B

$BF|6I%3%&%V%7!D(B4.0g,$BF|6I%;%s%-%e%&!D(B3.0g,$BF|6I%1%$%,%$!D(B2.0g,$BF|6I%O%C%+!D(B2.0g,$BF|6I%S%c%/%7!D(B2.0g,$BF|6I%\%&%U%&!D(B2.0g,$BF|6I%+%s%>%&!D(B1.5g,$B%-%g%&%+%D!D(B2.0g,$B%A%c%h%&!D(B1.5g
125 $B%D%`%i7K;^h*Nj4]2C0Ugo?N(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$V$/$j$g$&$,$s$+$h$/$$$K$s(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$,$"$j!";~$K2I(B:$B7n7PIT=g!"7l$NF;>I!"$K$-$S!"$7$_!"
$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$b$7$/$O$=$l0J>e$N?M$G!"$N$\$;$F@V$i4i$N$3$H$,B?$/!"2I>u$rG'$a!J7K;^h*Nj4]$N;HMQL\I8!K!"$5$i$KHiIf>I>u$,$"$k>l9g$KMQ$$$k!#(B
$B#1!KH)$N$"$l!"4NHC!":Bal!"aOlT$J$I$NHiIf>I>u$rH<$&>l9g!#(B
$B#2!KF,DK!"8*$3$j!"$a$^$$!"$N$\$;!"B-$NNd$($J$I$rH<$&>l9g!#(B
$B#3!KL57n7P!"2aB?7n7P!"7n7P:$Fq>I$J$I$N7n7P0[>o$N$"$kIX?M!#(B

$BF|6I%h%/%$%K%s!D(B10.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%7%c%/%d%/!D(B4.0g,$BF|6I%H%&%K%s!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%\%?%s%T!D(B4.0g
126 $B%D%`%iKc;R?N4](B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$7$K$s$,$s(B
$B-!!V8zG=!&8z2L!W(B
$BJXHk(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNOCfEyEY$"$k$$$O$d$dDc2<$7$??M$N=,47@-JXHk$G!"O7?M$dIB8e$N5u $B#1!KBgJX$O9E$/!"2t>u$rDh$9$k$3$H$,B?$$!#(B

$BF|6I%@%$%*%&!D(B4.0g,$BF|6I%-%8%D!D(B2.0g,$BF|6I%-%g%&%K%s!D(B2.0g,$BF|6I%3%&%\%/!D(B2.0g,$BF|6I%7%c%/%d%/!D(B2.0g,$B%^%7%K%s!D(B5.0g
127 $B%D%`%iKc2+Im;R:Y?IEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$^$*$&$V$7$5$$$7$s$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0-4(!"HyG.!"A4?H7qBU!"Dc7l05$GF,DK!"$a$^$$$,$"$j!";M;h$KaVDKNd46$"$k$b$N$NI(B:$B46KA!"5$4I;Y1j!#(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$N0-4($rH<$&H/G.!JHyG.!K$rL\I8$KMQ$$$k!#L.$OD@$s$G:Y$/!"NO$,$J$$$3$H$,B?$$!#O7?M$d5u $B#1!KL55$NO46!"A4?H7qBU46$J$I$rH<$&>l9g!#(B
$B#2!KF,DK!"31SV!"$N$I$NDK$_!"%/%7%c%_!"?eMM@-I!=A!"l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%931j>I:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%93?/32 $B#3!%:nMQ5!=x(B
$B!!!!!!93?/32
$BF|6I%^%*%&!D(B4.0g,$BF|6I%5%$%7%s!D(B3.0g,$B=$<#%V%7Kv!D(B1.0g
128 $B%D%`%i7 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B$d$;$F!"4i?'$,0-$/!"?)M_$,$J$/!"2I(B:$B0_D25uC2=ITNI!"2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$F$$$k?M$N2u$OE%>u$J$$$7$O?eMM$G$"$k>l9g$,B?$$!#(B
$B#1!K?)M_IT?6!"SREG!"J"DK$J$I$rH<$&>l9g!#(B
$B#2!KJ"It$,Fpl9g!#(B

$BF|6I%=%&%8%e%D!D(B4.0g,$BF|6I%V%/%j%g%&!D(B4.0g,$BF|6I%5%s%d%/!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%?%/%7%c!D(B2.0g,$BF|6I%A%s%T!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$B%l%s%K%/!D(B3.0g,$B%5%s%6%7!D(B2.0g
133 $B%D%`%iBg>55$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$@$$$8$g$&$-$H$&(B
$B-!8zG=!&8z2L!W(B
$BJ"It$,$+$?$/$D$+$($F!"JXHk$9$k$b$N!"$"$k$$$OHnK~BNo=,JXHk!"5^@-JXHk!"9b7l05!"?@7P>I!"?)Ev$j(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNNO$N=<l9g$KMQ$$$k!#(B
$B#1!KIT0B!"ITL2!"6=J3$J$I$N@:?@>I>u$rH<$&>l9g!#(B

$BF|6I%3%&%\%/!D(B5.0g,$BF|6I%-%8%D!D(B3.0g,$BF|6I%@%$%*%&!D(B2.0g,$BL5?e%\%&%7%g%&!D(B1.3g
134 $B%D%`%i7K;^2CgiLtBg2+Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$1$$$7$+$7$c$/$d$/$@$$$*$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BHf3SE*BNNO$N$J$$?M$G!"J"ItKDK~$7!"D2Fb$NDdBZ46$"$k$$$OJ"DK$J$I$rH<$&$b$N$NI(B:
1.$B5^@-D21j!"BgD2%+%?%k(B
2.$B>o=,JXHk!"=IJX!"$7$V$jJ"(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J"ItKDK~$7!"J"DK$,$"$j!"N"5^8e=E$rH<$&2l9g$KMQ$$$k!#(B
$B#1!KJX0U$r:E$9$,!"2w$/GSJX$7$J$$>l9g!#(B
$B#2!K2<:^I~MQ8e$NJ"DK!#(B
$B#3!K3+J"=Q8e$KJX$N2wDL$7$J$$>l9g!#(B

$BF|6I%7%c%/%d%/!D(B6.0g,$BF|6I%1%$%R!D(B4.0g,$BF|6I%?%$%=%&!D(B4.0g,$BF|6I%+%s%>%&!D(B2.0g,$BF|6I%@%$%*%&!D(B2.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g
135 $B%D%`%ih!DDhfEr(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$$$s$A$s$3$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$BG"NL8:>/!"$d!5JXHk$,$A$GHf3SE*BNNO$N$"$k$b$N$NI(B:$B2+aU!"4N9EJQ>I!"%M%U%m!<%
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$N$"$k?M$G!">eJ"It$h$j6;It$K$+$1$F$NKDK~46!"IT2w46$rAJ$(!"0-?4!"JXHk$rH<$&>l9g$KMQ$$$k!#(B
$B#1!K2+aU$N$"$k>l9g!#(B
$B#2!K8}3i!"G"NL8:>/!"HiIfGBaZ46$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B#1!%4N>c32$KBP$9$k:nMQ!J%i%C%H!"%^%&%9!K(B
$B#2!%MxC@:nMQ!J%i%C%H!K(B
$B#3!%:nMQ5!=x!!(B
$B!!!!!!!!4N>c32$KBP$9$k:nMQ!J(Bin vitro$B!K(B

$BF|6I%5%s%7%7!D(B3.0g,$BF|6I%@%$%*%&!D(B1.0g,$B%$%s%A%s%3%&!D(B4.0g
136 $B%D%`%i@6=k1W5$Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$;$$$7$g$($C$-$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B=k5$$"$?$j!"=k$5$K$h$k?)M_IT?6!&2
$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"?)M_IT?6!"A4?H7qBU46$rAJ$($k>l9g$KMQ$$$k!#(B
$B#1!KFpJX!"G"NL8:>/!"<+A3H/4@!"l9g!#(B
$B#2!K$$$o$f$k2F$d$;!"2F$^$1$KB?MQ$5$l$k!#(B

$BF|6I%=%&%8%e%D!D(B3.5g,$BF|6I%K%s%8%s!D(B3.5g,$BF|6I%P%/%b%s%I%&!D(B3.5g,$BF|6I%*%&%.!D(B3.0g,$BF|6I%A%s%T!D(B3.0g,$BF|6I%H%&%-!D(B3.0g,$BF|6I%*%&%P%/!D(B1.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%4%_%7!D(B1.0g
137 $B%D%`%i2CL#5"g#Er(B
$B%(%-%9pyN3(B($B0eNEMQ(B)
$B$+$_$-$R$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B5uI(B:$BIO7l!"ITL2>I!"@:?@IT0B!"?@7P>I(B

$B-"!V;HMQL\I8!a>Z!W(B
$BBNI>u$rAJ$(!"HyG.$N$"$k>l9g$KMQ$$$k!#(B
$B#1!K2<7l!"EG7l!"I!=P7l$J$I$rH<$&>l9g!#(B
$B#2!KEp4@!"A4?H7qBU46!"?)M_IT?6$J$I$rH<$&>l9g!#(B

$B-#!VLt8z!&LtM}!W(B
$B93IT0B:nMQ!J%^%&%9!K(B

$BF|6I%*%&%.!D(B3.0g,$BF|6I%5%$%3!D(B3.0g,$BF|6I%=%&%8%e%D!D(B3.0g,$BF|6I%K%s%8%s!D(B3.0g,$BF|6I%V%/%j%g%&!D(B3.0g,$BF|6I%*%s%8!D(B2.0g,$BF|6I%5%s%7%7!D(B2.0g,$BF|6I%?%$%=%&!D(B2.0g,$BF|6I%H%&%-!D(B2.0g,$BF|6I%+%s%>%&!D(B1.0g,$BF|6I%7%g%&%-%g%&!D(B1.0g,$BF|6I%b%C%3%&!D(B1.0g,$B%5%s%=%&%K%s!D(B3.0g,$B%j%e%&%,%s%K%/!D(B3.0g
138 $B%D%`%i5K9 $B%(%-%9pyN3(B($B0eNEMQ(B)
$B$-$-$g$&$H$&(B
$B-!!V8zG=!&8z2L!W(B
$B0v9"$,$O$l$FDK$`I(B:$BY(Em1j!"Y(Em<~0O1j(B

$B-"!V;HMQL\I8!a>Z!W(B
$B0v!&9"It$N1j>I$G!"aVDK!"l9g$KMQ$$$k!#(B
$B#1!K7ZEY$NH/G.!"31SV!"S=ab!"Sk2<:$Fq$J$I$rH<$&$3$H$,B?$$!#(B

$BF|6I%+%s%>%&!D(B3.0g,$BF|6I%-%-%g%&!D(B2.0g
3020 $B%D%`%i$N@8Lt(B
$B%3%&%8%sKv(B($BD4:^MQ(B)
$B-!!V8zG=!&8z2L!W(B
$B4AJ}=hJ}$ND4:^$KMQ$$$k(B

$B!!(B
3021 $B%D%`%i$N@8Lt(B
$B=$<#%V%7Kv(B($BD4:^MQ(B)
$B-!!V8zG=!&8z2L!W(B
$B4AJ}=hJ}$ND4:^$KMQ$$$k(B

$B!!(B
501 $B%D%`%i;g1@9Q(B
$B$7$&$s$3$&(B
$B-!!V8zG=!&8z2L!W(B
$B2P=}!"<&3K$K$h$kaVDK!"fjLgNu=}(B

$B-"!V;HMQL\I8!a>Z!W(B
$BHf3SE*BNNO$NDc2<$7$??M$G!"J,HgJ*$N>/$J$$>l9g$KMQ$$$k!#(B
$B#1!K2P=}!"<&3K$K$h$kaVDK!"fjLgNv=}$KMQ$$$k!#(B

$B-#!VLt8z!&LtM}!W(B
$BAO=}<#L~B%?J:nMQ!J%i%C%H!"%^%&%9!K(B

$BF|6I%4%^L}!D(B100.0g,$BF|6I%7%3%s!D(B10.0g,$BF|6I%H%&%-!D(B10.0g$B!!F|6I%5%i%7%_%D%m%&!D(B27.0g,$BF|6IFZL}!D(B1.8g

$BCm0U!K>e5-4AJ}Lt$r#2=54VI~MQ$7$F$b8z2L$KK~B-$G$-$J$$>l9g$O!"Bg;34AJ}$ND49g4AJ}Lt!J%*!<%@!<%a%$%I!K$r$*4+$a$7$^$9!*(B
$BBg;34AJ}F2Lt6I$K!"0lEY!"$*EEOC$/$@$5$$!#(B0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B

$B$*Ld$$9g$o$;$O!"(B
$B4AJ}$r8=BeIB$K3h$+$9!*4AJ}@lLg!!Bg;34AJ}F2Lt6I(B
0283-22-1574$B!JBg;34AJ}$G!"%$%4!&IT0B!&%J%7!K(B
$B$^$G!"$*5$7Z$K$*Ld$$9g$o$;$/$@$5$$!#(B


$BBg;34AJ}F2Lt6I(B
$B4AJ}7r9/AjCL%3!<%J!<$X!"%/%j%C%/!*(B




$B:4LnLq=|$1Bg;UDL$j$N4AJ}@lLg!"Bg;34AJ}F2Lt6I!!(BWeb-Page $B$X!"#G#o!*!*!*(B

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B

$B0eLtIJ$O;HMQ>e$NCm0U$r$*FI$_$$$?$@$-!"@5$7$/$*;H$$$/$@$5$$!#(B
$B$*Gc$$5a$a$N:]$K$O!"4AJ}$r8=BeIB$K3h$+$9(B $B4AJ}@lLg(B $BBg;34AJ}Lt6I$K!"$*5$7Z$K$4AjCL$/$@$5$$!#(B


$B!V%$%s%?!<%M%C%H$G8+$?!*!W(B
$B$H$*OC$/$@$5$$!#(B

$B!JCm0U!K(B
$B4AJ}@lLg!!Bg;34AJ}F2Lt6I$N!!87A*!"4AJ}Lt!"7r9/?)IJ$N$4CmJ8$O!"Bg;34AJ}Lt6I$K!"D>@\!"$*EEOC!"(BFAX$B!"(BE-mail $B$K$F$4MQL?$/$@$5$$!#(B
$B$*EEOC!'(B0283-22-1574$B!"(BFAX$B!'(B0283-22-1607$B!"(BE-mail:ohyama@poem.ocn.ne.jp
$B$*BT$ACW$7$F$*$j$^$9!#(B


$B!VBg;34AJ}F2(B $B4AJ}0e3X$H4AJ}7r9/AjCL!W(B

$B!!!!!!!!!!(B$B!!Bg;34AJ}F2Lt6I$NF@0U$H$9$kIB5$!"Bg;34AJ}F2Lt6I$K4AJ}AjCL$N$"$k$4IB5$0lMw!"(B

$B!!!!Bg;34AJ}F2Lt6I(B $B4AJ}7r9/AjCLAk8}!"0e3XGn;NBg;3Gn9T@h@8!"0e3XGn;N>.>>Lw90@h@8$N$4>R2p(B

" THE KAMPO " $B4AJ}(B
$B!!4AJ}Lt(B, How the Japanese Updated Traditional Herbal Medicine


$B!c4AJ}Lt$N$4I~MQ$r$*9M$($N3'MM$X$N$*4j$$!*!d(B

$B!v4AJ}Lt$N$4I~MQ$K4X$7$^$7$F$O!"(B
$B!V;HMQ>e$NCm0U!W$r$h$/FI$_!"!VMQK!!&MQNL!W$r$h$/
$B$^$?!":#2s!";O$a$F!"4AJ}Lt$N$4I~MQ$r4uK>$5$l$k$*5RMM$O!"(B
$B2<5-!"Ld?GI=$KI,MW;v9`$r5-F~$7$FAw?.$9$k$+!"(B

$B4AJ}AjCL$*?=$79~$_%U%)!<%`(B

$B$*EEOC$K$F!"D>@\!"Bg;34AJ}Lt6I$K!"$4AjCL$/$@$5$$!#(B
$B>I>u!&BN\$7$/$*;G$$$7$?>e$G!"E,@Z$J4AJ}Lt$r%"%I%P%$%9$5$;$FD:$-$^$9!#(B

$B!JBg;34AJ}Lt6I(B / $BL5NA4AJ}AjCLEEOC(B $B#0#2#8#3(B-$B#2#2(B-$B#1#5#7#4(B / $B#9!'#0#0!A#1#9!'#0#0!K(B

$B!cCm0U!d(B
$BBg;34AJ}Lt6I!"%G%8%?%kE9J^$G!"$*
$B0J>e!"$h$m$7$/$*4j$$CW$7$^$9!#(B

E-mail to Dr. Ohyama Kampo Pharmacy.


$B!!4AJ}$r8=BeIB$K3h$+$9!*!!4AJ}@lLg!!Bg;34AJ}Lt6I%G%8%?%kE9J^$X!*(B



$BBg;34AJ}F2Lt6I(B $B")(B327-0026$B!!FJLZ8):4Ln;T6b20CgD9D.#2#4#3#2(B
TEL$B!u(BFAX : 0283-22-1574$B!!(B E-mail : ohyama@poem.ocn.ne.jp

$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B$B!!(B