AGE-RELATED DIFFERENCES IN SYNAPTOSOMAL MEMBRANE FLUIDITY$B!!(B
Hiroyuki Ohyama, Midori Hiramatsu, Norio
Ogawa, Akitane Mori
Biochemistry and Molecular Biology International
37,133-140,1995

Department of Neuroscience, Institute of
Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1
Shikatacho, Okayama 700,
Japan and *Division of Medical Science, Institute
for Life Support Technology,
Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata
990, Japan

Biochemistry and Molecular Biology International
Notice of Acceptance
I am pleased to advise you that your paper
-
Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
$B!!!!!!!!!!!!!!!!!!!!(B
Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
in 1995.
HAS BEEN ACCEPTED FOR PUBLICATION IN
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL
The manuscript has been forwarded to the
publisher

Biochemistry and Molecular Biology International
Notice of Acceptance
Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
in 1995.
Yours sincerely,
The office of Dr. Lester Packer
for The Editors
Date. 8/15/95

ACKNOWLEDGEMENTS
We thank Dr. Lester Packer of the University of California,
Berkeley,
for reading our manuscript and providing us with valuable
comments.
Dr. Lester Packer of the University of California,Berkeley.
Biochemistry and
Molecular Biology International$B!J(BBMBI$B!K(B.
Special
Thanks.
Dr. Lester Packer
Building 20 - 251 LSA
Energy &
Environment Division
Lawrence Berkeley Laboratory
University of
California
Berkeley, CA 94720
$BBg;3Gn9T0e3XGn;N$O!"(B1990$BG/Be$K%7%J%W%H%=!<%`!J?@7P=*Kv!K$NKlN.F0@-$H;@2=%9%H%l%9$K>GE@$rEv$F!"?@7PO72=$K4X$9$k1F6ANO$N$"$k8&5f$r9T$$$^$7$?(B[1]$B!#(B
$B2,;3Bg3X$*$h$S;37A%F%/%N%]%j%9:bCD$H$N6&F18&5f$K$*$$$F!"Bg;3Gn;N$N8&5f$O!"F|K\$N4AJ}Lt!J(BTJ-960$B5Z$S4XO"@8Lt!K$,!"(B
$BG>Fb$N;i
$B%l%9%?!
$BO72=B%?J%^%&%9!J(BSAMP8$B!K$K$*$1$k0l;@2=CbAG$NF0BV$K$D$$$F$bD4::$,9T$o$l$F$$$^$9(B[6, 12]$B!#(B
$B0J2$NO72=!W$KBP$7$F$I$N$h$&$J%"%W%m!<%A$G8&5f$7$F$$$?$+$r@bL@$7$^$9!#(B
$B-!KlN.F0@-!J(BMembrane Fluidity$B!K$X$NCmL\(B
$B:YK&$NKl$OK\Mh!"1UBN$N$h$&$K=@Fp!JN.F0E*!K$G$9$,!"2CNp$H$H$b$K9E$/$J$j$^$9!#(B
$BKl$,9E$/$J$k$H!"?@7PEAC#J*
$BBg;3Gn;N$O!"O72=$K$h$C$F$3$N!VN.F0@-!W$,$I$&JQ2=$9$k$+$r8&5f$7$^$7$?!#(B
$B-";@2=%9%H%l%9$H4AJ}Lt!J(BTJ-960$B!K(B
$BG>$,;@2=!J%5%SIU$/$3$H!K$9$k$H!";iuBV$K$J$j!"O72=$rAa$a$^$9!#(B
$B8&5f$G$O!"F|K\$N4AJ}!J(BTJ-960$B!K$,93;@2=:nMQ$r;}$A!"G>$N!V%5%S!W$rKI$$$GKl$N=@Fp@-$rJ]$D8z2L$,$"$k$3$H$r<(:6$7$F$$$^$9!#(B
$B-#(BSAMP8$B!JO72=B%?J%^%&%9!K$rMQ$$$?8!>Z(B
$BDL>o$h$j$bAa$/O72=$,?J$`FC
$B$3$l$O!"G'CN>I$dG>5!G=Dc2<$N%a%+%K%:%`2rL@$K7R$,$k=EMW$J%9%F%C%W$G$9!#(B
$B-$9q:]E*$JI>2A(B
$B!V93;@2=J*
$BEv;~$N@$3&$NBh0l@~$GG'$a$i$l$F$$$?8&5f$G$"$k$3$H$,$o$+$j$^$9!#(B
$B$3$3$G>R2p$7$F$$$kO@J872$O!"(B**$B!V2CNp$K$h$kG>$NJQ2=$r2=3XE*$KB*$(!"$=$l$rE7A3M3Mh$N@.J,$G$I$&KI$0$+!W(B**
$B$H$$$&!"8=:_$N%"%s%A%(%$%8%s%0$d?@7P2J3X$N@h6n$1$H$J$kFbMF$G$9!#(B
Dr.HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
1)
Age-related difference in synaptosomal membrane
fluidity
Hiroyuki Ohyama, Midori Hiramatsu, Norio
Ogawa, Akitane Mori
Biochemistry and Molecular Biology International
37,133-140,1995
Department of Neuroscience, Institute of
Molecular and Cellular Medicine, Okayama
University Medical
School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute
for Life
Support Technology, Yamagata Technopolis
Foundation, Yamagata 683 Kurumanomae, Numagi,
Yamagata 990, Japan
2)
Effect of Japanese herbal medicine(TJ-960)
on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu,
Akitane Mori
Magnetic Resonance in Medicine 6, 279-281,
1995
3)
Effect of Japanese herbal medicine(TJ-960),
on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
Lipid-Soluble Antioxidants:Biochemistry and
Clinical Applications.
pp.535-552,Birkhauser Verlag,Basel,1992
4)
Combined treatment of Japanese herbal medicine(TJ-960)with
low dose of dipropylacetate increased the
latent time for
pentylenetetrazol induced convulsion and
decreased brain lipid peroxidation in mice.
Hiramatsu,M., Liu J, Edamatsu,R., Kadowaki,D.,
Hamada,H., Ohyama,H., Watanabe,S., Mori,A.
Neuroscience 18, 71-76,1992
5)
Estimation of nitric oxide and nitric oxide
synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H.,
Mori,A., Teraoka,H., Komaru,N.
in: The SAM Model of Senescence (T.Takeda,
ed.) pp.343-346,Elsevier Science B.V., Amsterdam,
1994
6)
Age-related changes in nitric oxide content
and nitric oxide synthase activity
in senescence-accelerated mouse (SAM P8)
brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A.,
Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y.,
Nishijima,K.
in: Oxidative Stress and Aging (R.G.Cutler,
L.Packer, J.Bertram, A.Mori, eds.)
pp387-391, Birkhauser Verlag, Basel, 1995
7)
UNESCO / Costam Workshop on Lipid-soluble
Antioxidants in Biochemistry of Nutrition
and Environmental Health
1991.9.21 (Malaysia)
Effect of Japanese herbal medicine(TJ-960),
on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
8)
Society for Free Radical Research 1991.9027
(Paris)
Japanese herbal medicine(TJ-960) affected
free radicals, SOD activity,
lipid peroxidation and neurotransmitter in
aged rat brain
Midori Hiramatsu, Rei Edamatsu, Hiroyuki
Ohyama, Akitane Mori
9)
5th International Congress on Oxygen Radicals
1991.11.18 (Kyoto)
Decreased membrane fluidity in rat synaptosomes
induced by active oxygen species,
guanidino compounds and convulsants
Midori Hiramatsu, Rei Edamatsu, Hajime Hamada,
Hiroyuki Ohyama, Akitane Mori
10)
5th International Congress on Oxygen Radicals
1991.11.20 (Kyoto)
Antioxidant effects of the extracts of gastrodia
fleta bl. and uncaria rhynchophylla (MJQ)
jacks
Jiankang Liu, Hajime Hamada, Hiroyuki Ohyama,
Akitane Mori.
11)
The First International Conference on Senescence:
The SAM Model 1994.3.17 (Kyoto)
Estimation of nitric oxide and nitric oxide
synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H.,
Mori,A., Teraoka,H., Komaru,N.
12)
The First International Conference on Oxidative
Stress and Aging 1994.3.25 (Hawaii)
Age-associated changes in nitric oxide (NO)
content and nitric oxide synthase (NOS) activity
in senescence accelerated mouse (SAM P8)
brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A.,
Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y.,
Nishijima,K.
13)
International Conference on Bioradicals Detected
by ESR Spectroscopy 1994.6.13 (Yamagata)
Effect of Japanese herbal medicine(TJ-960)
on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu,
Akitane Mori
14)
International Symposium on Natural Antioxidants:
Molecular Mechanisms and Health Effects (ISNA)
1995.6.21 (Beijin)
Antioxidant defenses of Japanese herbal medicine(TJ-960)
, against free radical induced neural cell
damages
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama,
Midori Hiramatsu, Seiichi Shinohara
Dr.HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
